publication . Other literature type . Article . 2017 . Embargo end date: 01 Jan 2017

The effect of wound dressings on a bio-engineered human dermo-epidermal skin substitute in a rat model

Martina Hüging; Thomas Biedermann; Monia Sobrio; Sarah A. Meyer; Sophie Böttcher-Haberzeth; Edith Manuel; Maya Horst; Sally Hynes; Ernst Reichmann; Clemens Schiestl; ...
Open Access
  • Published: 01 Jan 2017
  • Publisher: Lippincott Williams & Wilkins
  • Country: Switzerland
Autologous bio-engineered dermo-epidermal skin substitutes are a promising treatment for large skin defects such as burns. For their successful clinical application, the graft dressing must protect and support the keratinocyte layer and, in many cases, possess antimicrobial properties. However, silver in many antimicrobial dressings may inhibit keratinocyte growth and differentiation. The purpose of our study was to evaluate the effect of various wound dressings on the healing of a human hydrogel-based dermo-epidermal skin substitute in preparation for the first-in-human clinical trials. Human dermo-epidermal skin substitutes approved for clinical trials were pr...
Medical Subject Headings: integumentary system
free text keywords: Clinic for Surgery, 610 Medicine & health, Random allocation, Rat model, Graft survival, Vaseline, Clinical trial, Medicine, business.industry, business, Wound healing, Skin substitutes, Keratinocyte, medicine.anatomical_structure, Dermatology, medicine.medical_specialty
Related Organizations
Funded by
Training Multidisciplinary scientists for Tissue Engineering and Regenerative Medicine
  • Funder: European Commission (EC)
  • Project Code: 238551
  • Funding stream: FP7 | SP3 | PEOPLE
A novel generation of skin substitutes to clinically treat a broad spectrum of severe skin defects
  • Funder: European Commission (EC)
  • Project Code: 279024
  • Funding stream: FP7 | SP1 | HEALTH
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