Transcription factor Fos-Related Antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis

Article, Other literature type English OPEN
Maurer, B; Busch, N; Jüngel, A; Pileckyte, M; Gay, R E; Michel, B A; Schett, G; Gay, S; Distler, J; Distler, O;
  • Publisher: Lippincott Wiliams & Wilkins
  • Embargo end date: 2009
  • Related identifiers: doi: 10.1161/CIRCULATIONAHA.109.855114, doi: 10.5167/uzh-24982
  • Subject: 610 Medicine & health | Rheumatology Clinic and Institute of Physical Medicine | 570 Life sciences; biology | Center for Integrative Human Physiology

BACKGROUND: -Microvascular damage is one of the first pathological changes in systemic sclerosis. In this study, we investigated the role of Fos-related antigen-2 (Fra-2), a transcription factor of the activator protein-1 family, in the peripheral vasculopathy of system... View more