Transcription factor Fos-Related Antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis
Gay, R E
Michel, B A
- Publisher: Lippincott Wiliams & Wilkins
Center for Integrative Human Physiology | Rheumatology Clinic and Institute of Physical Medicine | 570 Life sciences; biology | 610 Medicine & health
BACKGROUND: -Microvascular damage is one of the first pathological changes in systemic sclerosis. In this study, we investigated the role of Fos-related antigen-2 (Fra-2), a transcription factor of the activator protein-1 family, in the peripheral vasculopathy of system...