publication . Other literature type . Article . 2011 . Embargo end date: 01 Jan 2011

Altered medial temporal activation related to local glutamate levels in subjects with prodromal signs of psychosis.

Valli, I; Stone, J; Mechelli, A; Bhattacharyya, S; Raffin, M; Allen, P; Fusar-Poli, P; Lythgoe, D; O'Gorman, R; Seal, M; ...
  • Published: 01 Jan 2011
  • Publisher: Elsevier
  • Country: Switzerland
Abstract
Background Both medial temporal cortical dysfunction and perturbed glutamatergic neurotransmission are regarded as fundamental pathophysiological features of psychosis. However, although animal models of psychosis suggest that these two abnormalities are interrelated, their relationship in humans has yet to be investigated. Methods We used a combination of functional magnetic resonance imaging and magnetic resonance spectroscopy to investigate the relationship between medial temporal activation during an episodic memory task and local glutamate levels in 22 individuals with an at-risk mental state for psychosis and 14 healthy volunteers. Results We observed a si...
Subjects
free text keywords: Medical Clinic, 610 Medicine & health, Biological Psychiatry, Glutamate receptor, Population, education.field_of_study, education, Neurotransmission, Psychosis, medicine.disease, medicine, Episodic memory, Neuroscience, Endocrinology, medicine.medical_specialty, Psychiatry, Internal medicine, Glutamatergic, Schizophrenia, Psychology, Functional magnetic resonance imaging, medicine.diagnostic_test
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publication . Other literature type . Article . 2011 . Embargo end date: 01 Jan 2011

Altered medial temporal activation related to local glutamate levels in subjects with prodromal signs of psychosis.

Valli, I; Stone, J; Mechelli, A; Bhattacharyya, S; Raffin, M; Allen, P; Fusar-Poli, P; Lythgoe, D; O'Gorman, R; Seal, M; ...