publication . Article . 1990

The influence of hydrophobic solvation on the alkaline hydrolysis of ethyl esters of polar substituted 2-methylpropionic acids in water

G. Schmeer; S. Riembauer; J. Barthel;
Open Access English
  • Published: 01 Jan 1990
  • Publisher: Plenum; Kluwer; Springer
  • Country: Germany
Abstract
The rate constants of the alkaline hydrolysis of 2-methylpropionic acid ethyl ester, alpha-hydroxy, alpha-bromo, alpha-cyano, and alpha-nitro-2-methylpropionic acid ethyl ester have been measured in water between 5-degrees-C and 45-degrees-C with the help of an appropriate conductance bridge developed in our laboratory. The influence of the polar substituents on the rate constant, a powerful probe for discussing two-particle interactions in solutions, is characterized by an intramolecular structure parameter of the activated complex and a dielectric parameter of its surroundings. The dependence of the reaction rate of the structure parameter is compared to that ...
Subjects
free text keywords: 540 Chemie, ddc:540, Physical and Theoretical Chemistry, Biophysics, Biochemistry, Molecular Biology, Inorganic chemistry, Hydrolysis, Organic chemistry, Alkaline hydrolysis (body disposal), Activated complex, Reaction rate, Acetic acid, chemistry.chemical_compound, chemistry, Reaction rate constant, Solvation, Intramolecular force, Medicinal chemistry
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