publication . Article . 2016

Progression of Late-Onset Stargardt Disease

Lambertus, S.; Lindner, M.; Bax, N.M.; Bax, N.M.; Mauschitz, M.M.; Nadal, J.; Schmid, M.; Schmitz-Valckenberg, S.; den Hollander, A.I.; den Hollander, A.I.; ...
Open Access
  • Published: 01 Jan 2016
Purpose: Identification of sensitive biomarkers is essential to determine potential effects of emerging therapeutic trials for Stargardt disease. This study aimed to describe the natural history of late-onset Stargardt, and demonstrates the accuracy of retinal pigment epithelium (RPE) atrophy progression as an outcome measure. Methods: We performed a retrospective cohort study collecting multicenter data from 47 patients (91 eyes) with late-onset Stargardt, defined by clinical phenotype, at least one ABCA4 mutation, and age at disease onset >/= 45 years. We analyzed RPE atrophy progression on fundus autofluorescence and near-infrared reflectance imaging using se...
Medical Subject Headings: eye diseases
free text keywords: 610 Medizin, ddc:610, Pathology, medicine.medical_specialty, medicine, Stargardt disease, medicine.disease, Late onset, Confidence interval, ABCA4, biology.protein, biology, Retrospective cohort study, Cohort study, Atrophy, Ophthalmology, Visual acuity, medicine.symptom, business.industry, business
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