publication . Article . Other literature type . 2017

Tissue-engineered trachea: History, problems and the future

Tan, Qiang; Steiner, Rudolf; Hoerstrup, Simon P.; Weder, Walter;
Open Access English
  • Published: 02 Aug 2017
  • Publisher: Elsevier
  • Country: Switzerland
Abstract
This review tries to summarize the efforts over the past 20 years to construct a tissue-engineered trachea. After illustrating the main technical bottlenecks faced nowadays, we discuss what might be the solutions to these bottlenecks. You may find out why the focus in this research field shifts dramatically from the construction of a tubular cartilage tissue to reepithelialization and revascularization of the prosthesis. In the end we propose a novel concept of 'in vivo bioreactor', defined as the design of a perfusion system inside the scaffold, and explain its potential application in the construction of a tissue-engineered trachea.
Subjects
free text keywords: Division of Surgical Research, 610 Medicine & health, Surgery, Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine, General Medicine, medicine.medical_specialty, medicine, Cartilage, medicine.anatomical_structure, Revascularization, medicine.medical_treatment, business.industry, business, Scaffold, Tissue engineering
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publication . Article . Other literature type . 2017

Tissue-engineered trachea: History, problems and the future

Tan, Qiang; Steiner, Rudolf; Hoerstrup, Simon P.; Weder, Walter;