publication . Doctoral thesis . 2009

Die Bedeutung von Fetuin-A für Proliferation und Fibrogenese im Knockout-Modell

Stojanov, Sabrina;
Open Access German
  • Published: 01 Jan 2009
  • Publisher: Publikationsserver der RWTH Aachen University
  • Country: Germany
Abstract
The human cirrhosis of the liver is a progressive illness with serious clinical results, like portal hypertension and terminal functional loss of the organ. At the end stands the liver transplant or the exitus letalis, not to forget the strongly raised prevalence for the hepatocellular carcinoma. For these reasons it is essential to develop new therapy concepts with views of forecast improvement or even healing. With a knockout model of the mouse we examined the effect of fetuin-A for physiological proliferation and pathological fibrogenesis of the liver. The rational was, that fetuin-A as a TGF-beta antagonist possibly adjusts the effects on proliferation and f...
Subjects
free text keywords: Proliferation, Fibrose, Medizin, Knockout-Modell, Fetiun-A, Fibrogenese, knockout model, fibrogenesis, ddc:610
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