publication . Doctoral thesis . 2015

Fibrin- versus Plasma-Gel Scaffolds - und der Einfluss von TGF-ß und bFGF auf Myofibroblasten und die Gewebeneogenese

Dietrich, Maren;
Open Access German
  • Published: 01 Jan 2015
  • Publisher: Publikationsserver der RWTH Aachen University
  • Country: Germany
Abstract
One central aspect in tissue engineering is the scaffold. Due to its properties and the direct contact to cells, it strongly influences the development of the tissue engineered construct. Especially attractive are autologous materials, like fibrin. To optimize autologous PFP- and fibrin-scaffolds this work compared the basic materials platelet free plasma (PFP), platelet poor plasma (PPP), and platelet rich plasma (PRP) as autologous materials for scaffold production. Three differently concentrated PPP and PRP-gels were used. Therefore the microstructure of gels, the mechanical strength, proliferation, ECM-development and neogenesis were analyzed. Furthermore th...
Subjects
free text keywords: Fibringel, Plasmagel, Scaffold, fibrin-gel scaffold, plasma-gel scaffolds, ddc:610
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