publication . Doctoral thesis . 2016

Einfluss pathophysiologischer Konzentrationen von Ammonium auf die Transkription und Funktion von Acid-Sensing Ion Channels (ASICs) in murinen Kortexneuronen

Bresenitz, Pia;
Open Access German
  • Published: 01 Jan 2016
  • Country: Germany
Abstract
Hepatic Encephalopathy is a central neuropsychologic disorder caused by liver failure. An increased ammonium concentration is believed to be one of the main players, resulting in changes in several neurotransmitter systems as well as in energy metabolism, both in neuronal and non-neuronal cells in the brain. This is accompanied by neuroinflammatory processes. These factors act synergistically and lead to worsening of the symptoms. AcidSensing Ion Channels (ASICs) are proton-gated cation channels that belong to the DEG/ENaC gene-family. ASIC1a, ASIC2a and ASIC2b are expressed in the mammalian brain as homo- and heteromeric channels. However, their function has no...
Subjects
free text keywords: acid-sensing ion channels, ASICs, hepatic encephalopathy, cortical neurons, liver failure, ddc:570
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