publication . Doctoral thesis . 2010

ITAM-like signalling for efficient phagocytosis : The paradigm of the granulocyte receptor CEACAM3

Pils, Stefan;
Open Access English
  • Published: 01 Jan 2010
  • Country: Germany
Human CEACAM3 is a tailor-made receptor of the innate immune system to fight pathogens exploiting epithelial CEACAM-family members for colonisation and invasion of their host. Previous studies established CEACAM3 as the receptor facilitating rapid phagocytosis and elimination of N. gonorrhoeae by human granulocytes. The studies reported here set out to shed light on the evolution of this highly specialised receptor and the associated signalling machinery.<br />CEACAM3 arose from exon shuffling after radiation of CEACAM1 approximately 24 million years ago in an ancestor of modern primates, bringing together the N-terminal domain of an epithelial CEACAM (CEACAM1, ...
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