publication . Doctoral thesis . 2008

Entwicklung von Cysteinproteaseinhibitoren - ein klassischer und ein kombinatorischer Ansatz zur Inhibitoroptimierung

Machon, Uwe Rainer;
Open Access German
  • Published: 01 Jan 2008
  • Country: Germany
The main goal of the thesis “Development of cysteine protease inhibitors – a classical and a combinatorial approach for inhibitor optimization” was the optimization of new inhibitors of falcipain-2 and rhodesain as new potential agents against malaria and the sleeping sickness by two different methods. That was a classical and a combinatorial method. The classical approach is based on a compound with a high activity against falcipain-2 which was discovered by chance. The structure-reactivity relations were to be developed in screenings of analogous compounds and by computational docking experiments in the active site of the cysteine proteases. The combinatorial ...
free text keywords: Enzyminhibitor, Peptidsynthese, Aminosäuren, Organische Synthese, Kombinatorische Synthese, Furanderivate, Guanidinderivate, ddc:540
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