publication . Doctoral thesis . 2008

Entwicklung von Cysteinproteaseinhibitoren - ein klassischer und ein kombinatorischer Ansatz zur Inhibitoroptimierung

Machon, Uwe Rainer;
Open Access German
  • Published: 01 Jan 2008
  • Country: Germany
Abstract
The main goal of the thesis “Development of cysteine protease inhibitors – a classical and a combinatorial approach for inhibitor optimization” was the optimization of new inhibitors of falcipain-2 and rhodesain as new potential agents against malaria and the sleeping sickness by two different methods. That was a classical and a combinatorial method. The classical approach is based on a compound with a high activity against falcipain-2 which was discovered by chance. The structure-reactivity relations were to be developed in screenings of analogous compounds and by computational docking experiments in the active site of the cysteine proteases. The combinatorial ...
Subjects
free text keywords: Enzyminhibitor, Peptidsynthese, Aminosäuren, Organische Synthese, Kombinatorische Synthese, Furanderivate, Guanidinderivate, ddc:540
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