publication . Doctoral thesis . 2015

Interaktionen des humanpathogenen Pilzes Aspergillus fumigatus mit dem angeborenen Immunsystem und Thrombozyten

Czakai, Kristin Bernadette;
Open Access German
  • Published: 01 Jan 2015
  • Country: Germany
Abstract
Fungi are ubiquitously distributed and around 50% of human mucosae are colonized by Candida albicans. Spores of Aspergillus fumigatus, called conidia, reach the human lung by inhalation of normal air. Still, fungi normally do not cause severe diseases in healthy individuals. Immunosuppression, however, predisposes to systematic and therefore life-threatening infection like invasive aspergillosis and systemic candidiasis. The treatment of those infections can only be improved by a detailed insight in immune defense mechanisms. The most prominent cell type in the lung, the location where A. fumigatus conidia can germinate and grow into tissue, are macrophages. Fur...
Subjects
free text keywords: Aspergillus fumigatus, Immunsystem, Thrombozyt, ddc:570
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