publication . Doctoral thesis . 2012

Synthese und Charakterisierung von potenziellen Inhibitoren des „Macrophage infectivity potentiator“ (Mip) Proteins von Legionella pneumophila - Ein neuer Ansatz in der Legionellose-Therapie

Juli, Christina;
Open Access German
  • Published: 01 Jan 2012
  • Country: Germany
The present work focused on the synthesis and characterization of potential inhibitors of the surface protein Mip of Legionella pneumophila. The gram-negative microorganism is the causative agent of Legionellosis, which may occur in two different progressive forms, the Pontiac fever, a flu-like respiratory disease, and the Legionnaires disease, a severe pneumonia with mortality rate of up to 30 %. Natural and man-made fresh water systems provide a biological habitat to the bacteria. From this environment they were transmitted into humans via technical vectors such as showers or air conditioners by inhaling the contaminated aerosols. Within the human lung, they a...
free text keywords: Legionella pneumophila, Legionärskrankheit, Marcophage-infectivity-potentiator-Protein, Pipecolinsäurederivate, ddc:540
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