publication . Article . 1985

Recombinant human interleukin 2 acts as a B cell growth and differentiation promoting factor.

Emmrich, F.; Moll, Heidrun; Simon, Markus M.;
Open Access
  • Published: 01 Jan 1985 Journal: Immunobiology, volume 169, pages 97-102 (issn: 0171-2985, Copyright policy)
  • Publisher: Elsevier BV
  • Country: Germany
Abstract
Abstract Human B cells appropriately activated by a B cell mitogen are rendered susceptible to human Interleukin 2 (IL-2) as demonstrated with recombinant human IL-2 (rec. h IL-2). They show increased proliferation and drastically enhanced immunoglobulin secretion. Susceptibility to IL-2 is accompanied with the expression of the IL-2 receptor (Tac antigen) on B cells. The data suggest that IL-2 is one of the lymphokines directly involved in the activation of B lymphocytes.
Subjects
free text keywords: Immunology, Immunology and Allergy, Hematology, B cell, medicine.anatomical_structure, medicine, Cellular differentiation, Naive B cell, Lymphokine, Biology, Molecular biology, Immunoglobulin secretion, B-cell receptor, Interleukin 2, medicine.drug, Interleukin, ddc:610
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publication . Article . 1985

Recombinant human interleukin 2 acts as a B cell growth and differentiation promoting factor.

Emmrich, F.; Moll, Heidrun; Simon, Markus M.;