publication . Doctoral thesis . 2008

CEACAM3-mediated phagocytosis of human-specific bacterial pathogens involves the adaptor molecule Nck

Peterson, Lisa;
Open Access English
  • Published: 01 Jan 2008
  • Country: Germany
Abstract
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are exploited by human-specific pathogens to anchor themselves to or invade host cells. Interestingly, human granulocytes express a specific isoform, CEACAM3, that can direct efficient, opsonin-independent phagocytosis of CEACAM-binding Neisseria, Moraxella and Haemophilus species. As opsonin-independent phagocytosis of CEACAM-binding Neisseria depends on Src-family protein tyrosine kinase (PTK) phosphorylation of the CEACAM3 cytoplasmic domain, we hypothesized that an SH2-containing protein might be involved in CEACAM3-initiated, phagocytosis-promoting signals. Accordingly, we screened glutathio...
Subjects
Medical Subject Headings: animal structures
free text keywords: Adaptorproteine, Signaltransduktion, Phagozytose, Neisseria gonorrhoeae, Carcino-embryonales Antigen, Angeborene Immunität, Src-Proteine, Nichtrezeptor-Tyrosinkinasen, ddc:610
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