publication . Article . 1985

Recombinant human interleukin 2 directly provides signals for the proliferation and functional maturation of murine B lymphocytes.

Open Access English
  • Published: 01 Jan 1985
  • Country: Germany
Abstract In this study the effect of recombinant human interleukin 2 (rec.hIL-2) on the proliferationand maturation of B lymphocytes was investigated. It was found that the presence of rec.hIL 2 results in proliferation of mitogen (LPS)-activated B cell blasts. In addition, it is shown that highly enriched murine B cells can be induced by rec.hIL-2 to proliferate and to develop into antibody-secreting cells (PFC) in the presence of antigen (SRBC). When tested for its effect on B cell preparations enriched for resting (small) or activated (blasted) B lymphocytes, it was found that rec.hIL 2 provides signals for both B cell populations to develop into PFC. In cont...
Medical Subject Headings: endocrine system
free text keywords: ddc:610, Immunology, Immunology and Allergy, Hematology, Cellular differentiation, Biology, B-1 cell, Interleukin, Cell growth, Molecular biology, Lymphokine, Naive B cell, Antigen, B cell, medicine.anatomical_structure, medicine
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