publication . Article . 2010

Asymmetric organocatalytic Michael addition of Meldrum's acid to nitroalkenes: probing the mechanism of bifunctional thiourea organocatalysts

Kataja, Antti O.; Ari Koskinen;
Open Access English
  • Published: 01 May 2010
  • Country: Finland
Abstract
The asymmetric Michael addition of Meldrum’s acid to nitroalkenes was studied using a novel type of Cinchona alkaloid-based bifunctional thiourea organocatalyst. The functionality of the thiourea catalysts was also probed by preparing and testing thiourea-N-methylated analogues of the well-known bis-(3,5-trifluoromethyl)phenyl-substituted catalyst. Peer reviewed
Subjects
free text keywords: 116 Chemical sciences, Asymmetric, organocatalytic, Asymmetric, organocatalytics, Michael addition, bifunctional thiourea catalysts, cinchona alkaloids, Meldrum's acid, Organic chemistry, QD241-441
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