publication . Article . 2010

Asymmetric organocatalytic Michael addition of Meldrum's acid to nitroalkenes: probing the mechanism of bifunctional thiourea organocatalysts

Antti O. Kataja; Ari M. P. Koskinen;
Open Access
  • Published: 01 May 2010
  • Country: Finland
Abstract
The asymmetric Michael addition of Meldrum’s acid to nitroalkenes was studied using a novel type of Cinchona alkaloid-based bifunctional thiourea organocatalyst. The functionality of the thiourea catalysts was also probed by preparing and testing thiourea-N-methylated analogues of the well-known bis-(3,5-trifluoromethyl)phenyl-substituted catalyst. Peer reviewed
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free text keywords: 116 Chemical sciences, Asymmetric, organocatalytic, Asymmetric, organocatalytics, Michael addition, bifunctional thiourea catalysts, cinchona alkaloids, Meldrum's acid, Organic Chemistry, Bifunctional, chemistry.chemical_compound, chemistry, Cinchona, biology.organism_classification, biology, Thiourea, Michael reaction, Catalysis, lcsh:Organic chemistry, lcsh:QD241-441
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