Asymmetric organocatalytic Michael addition of Meldrum's acid to nitroalkenes: probing the mechanism of bifunctional thiourea organocatalysts

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Kataja, Antti O.; Koskinen, Ari M.P.;
  • Subject: 116 Chemical sciences | Asymmetric, organocatalytic | Asymmetric | organocatalytics | Michael addition | bifunctional thiourea catalysts | cinchona alkaloids | Meldrum's acid

The asymmetric Michael addition of Meldrum’s acid to nitroalkenes was studied using a novel type of Cinchona alkaloid-based bifunctional thiourea organocatalyst. The functionality of the thiourea catalysts was also probed by preparing and testing thiourea-N-methylated a... View more
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