publication . Doctoral thesis . 2013

Molekulare Identifizierung und Charakterisierung der Flavin-abhängigen Monooxygenasen in verschiedenen Pyrrolizidin-Alkaloid-adaptierten Insekten

Wang, Linzhu;
Open Access German
  • Published: 05 Feb 2013
  • Country: Germany
Abstract
Several insect lineages have developed diverse strategies to sequester toxic pyrrolizidine alkaloids from food-plants for their own defense. Here, we show that in two highly divergent insect taxa, the hemimetabolous grasshoppers and the holometabolous butterflies, an almost identical strategy evolved independently for safe accumulation of pyrrolizidine alkaloids. This strategy involves a pyrrolizidine alkaloid N-oxygenase that transfers the pyrrolizidine alkaloids to their respective N-oxide, enabling the insects to avoid high concentrations of toxic pyrrolizidine alkaloids in the hemolymph. We have identified a pyrrolizidine alkaloid N-oxygenase, which is a fla...
Subjects
Medical Subject Headings: heterocyclic compoundscomplex mixturesorganic chemicalsendocrine system
free text keywords: Mathematisch-Naturwissenschaftliche Fakultät, Faculty of Mathematics and Natural Sciences, Evolution, Biochemische Ökologie, Flavin-abhängige Monooxygenase, Pyrrolizidin-Alkaloide, Insekten, Arctia caja, Danaus plexippus, Grammia geneura, Zonocerus variegatus, Tyria jacobaeae, Abschlussarbeit, doctoral thesis, Evolution, Biochemische Ökologie, Flavin-abhängige Monooxygenase, Pyrrolizidin-Alkaloide, Insekten, Arctia caja, Danaus plexippus, Grammia geneura, Zonocerus variegatus, Tyria jacobaeae, ddc:570, ddc:5XX
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