publication . Doctoral thesis . 2017

Understanding interparticle interactions in dry powder inhalation : glass beads as an innovative model carrier system

Renner, Niklas Ludwig;
Open Access English
  • Published: 13 Oct 2017
  • Country: Germany
Abstract
Delivery of drugs via the pulmonary route is the most common approach to treat diseases of the respiratory system, e.g. asthma bronchiale. Here, the active pharmaceutical ingredient is generally formulated in a so-called interactive mixture with a coarse and inert carrier. This enhances flowability and therefore dose metering and dispersibility. Interparticle interactions between carrier and drug govern aerosolisation behaviour of the blend and consequently the efficacy of the drug deposition in the lungs. These interactions, for their part, are influenced by a variety of factors including chemical and topographical properties of the carrier surface. To investig...
Subjects
free text keywords: Mathematisch-Naturwissenschaftliche Fakultät, Faculty of Mathematics and Natural Sciences, Inhalation glass beads interparticle interactions, Abschlussarbeit, doctoral thesis, Inhalation, glass, beads, interparticle, interactions, ddc:500, ddc:5XX
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