publication . Article . 2013

COULD SERUM LAMININ REPLACE LIVER BIOPSY AS GOLD STANDARD FOR PREDICTING SIGNIFICANT FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B? CLINICAL AND HISTOPATHOLOGICAL STUDY

Abeer M. Hafez; Yasser S. Sheta; Mohamed H. Ibrahim; Shereen A. Elshazly;
Open Access
  • Published: 01 Jan 2013
Abstract
Background: The prognosis and clinical treatment of chronic liver disease depends greatly on the progression of liver fibrosis, which has resulted from the loss of normal liver cell function due to disorganized over-accumulation of extra-cellular matrix (ECM) components in the liver. Liver biopsy has been considered the gold standard for staging and grading hepatic fibrosis and inflammation. However, the procedure is associated with complications such as bleeding, infection, damage to liver tissue, and it is difficult to put into practice. Aim of the work: To evaluate the diagnostic performance of serum laminin (LN) as serum markers for predicting significant fi...
Subjects
free text keywords: Serum laminin, Chronic hepatitis B, Radio immune assay
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