Perfil de ácidos grasos de hígados de ratones alimentados con una dieta cetogénica basada en triheptanoína

Article English OPEN
Meloi, Ingrid Sofia Vieira de; Ataidei, Terezinha da Rocha; Oliveirai, Suzana Lima de; Bezerra Buenoi, Nassib; Freitasi, Johnnatan Duarte de; Sant'Anai, Antônio Euzébio Goulart;
(2015)
  • Publisher: Grupo Arán
  • Subject: Triheptanoína | Ketogenic diet | Medium-chain triacylglycerols | Trienantin | Ácidos grasos | Fatty acid profile | Ratones Wistar

Objective: the aim of this study was to evaluate the influence of consumption of a ketogenic diet supplemented with triheptanoin, a medium-chain anaplerotic triacylglycerol, on the liver fatty acid profile of Wistar rats. Methods: three groups of male Wistar rats (n = 1... View more
  • References (21)
    21 references, page 1 of 3

    1. Levy RG, Cooper PN, Giri P. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database. Syst Rev 2012; 3: CD001903.

    2. Neal EG, Chaffe H, Schwartz RH, Lawson MS, Edwards N, Fitzsimmons G, et al. A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia 2009; 50: 1109-1117.

    3. Roe CR, Sweetman L, Roe DS, David F, Brunengraber H. Treatment of cardiomyopathy and rhabdomyolysis in longchain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest 2002; 110: 259-269.

    4. Kim TH, Borges K, Petrou S, Reid CA. Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy. Epilepsy Res 2013; 103: 101-105.

    5. Willis S, Stoll J, Sweetman L, Borges K. Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models. Neurobiol Dis 2010; 40: 565-572.

    6. Borges K, Sonnewald U. Triheptanoin - a medium chain triglyceride with odd chain fatty acids: a new anaplerotic anticonvulsant treatment? Epilepsy Res 2012; 100: 239-244.

    7. Gama IR, Trindade-Filho EM, Oliveira SL, Bueno NB, Melo IT, Cabral-Junior CR, da Rocha Ataide, T. (2014). Effects of ketogenic diets on the occurrence of pilocarpine-induced status epilepticus of rats. Metabolic brain disease, 1-6.

    8. Roe CR, Mochel F. Anaplerotic diet therapy in inherited metabolic disease: Therapeutic potential. J Inherit Metab Dis 2006; 29: 332-340.

    9. Mochel F, Delonlay P, Touat G, Brunengraber H, Kinamn RP, Rabier D, et al. Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy. Mol Genet Metab 2005; 84: 305-312.

    10. Ataíde TR, Oliveira SL, Da Silva FM, Vitorino Silva LGC, Tavares MCN, Sant'Ana AEG. Toxicological analysis of the chronic consumption of diheptanoin and triheptanoin in rats. Int J Food Sci and Tech 2009; 44: 484-492.

  • Similar Research Results (1)
  • Related Organizations (1)
  • Metrics
Share - Bookmark