publication . Article . 2016

Oxidative stress as a possible therapeutic target for osteoporosis associated with aging

Portal-Núñez S; de la Fuente M; Díez A; Esbrit P;
Open Access Spanish
  • Published: 01 Dec 2016
  • Publisher: Sociedad Española de Investigaciones Óseas y Metabolismo Mineral
Abstract
La osteoporosis senil o involutiva es un problema de primera magnitud en el mundo desarrollado. Estudios recientes apuntan al aumento del estrés oxidativo asociado al envejecimiento -cronológico o biológico- como un factor importante en su desarrollo. En esta revisión nos centraremos en las alteraciones del tejido óseo con la edad, en el origen del estrés oxidativo y su influencia negativa en el tejido óseo. Finalmente, abordaremos las posibles terapias antiestrés oxidativo que actualmente se encuentran en desarrollo en esta patología. Senile or involutional osteoporosis is a major problem in the developed world. Recent studies point to increased oxidative stres...
Subjects
free text keywords: estrés oxidativo, osteoporosis, envejecimiento, fragilidad, oxidative stress, aging, fragility, lcsh:Medicine, lcsh:R, lcsh:Osteopathy, lcsh:RZ301-397.5
78 references, page 1 of 6

Osteoporos Int. 1992;2:285-9.

Reginster J-Y, Burlet N. Osteoporosis: a still increasing prevalence. Bone. 2006;38:S4-9.

Khosla S, Riggs BL. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am. 2005;34:1015-30, xi. [OpenAIRE]

Van Staa TP, Laan RF, Barton IP, Cohen S, Reid DM, Cooper C. Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum. 2003;48:3224-9.

Diabetes and its complications and their relationship with risk of fractures in type 1 and 2 diabetes. Calcif Tissue Int. 2009;84:45-55.

Miller PD. Bone disease in CKD: a focus on osteoporosis diagnosis and management. Am J Kidney Dis. 2014;64:290-304.

8. Eriksen EF. Cellular mechanisms of bone remodeling. Rev. Endocr. Metab Disord. 2010;11:219-27.

9. Bailey AJ, Knott L. Molecular changes in bone collagen in osteoporosis and osteoarthritis in the elderly. Exp Gerontol. 1999;34:337-51.

10. Wang L, Banu J, McMahan CA, Kalu DN. Male rodent model of age-related bone loss in men. Bone. 2001;29:141-8.

11. Liang CT, Barnes J, Seedor JG, Quartuccio HA, Bolander M, Jeffrey JJ, et al. Impaired bone activity in aged rats: alterations at the cellular and molecular levels. Bone. 1992;13:435-41.

12. Roholl PJ, Blauw E, Zurcher C, Dormans JA, Theuns HM. Evidence for a diminished maturation of preosteoblasts into osteoblasts during aging in rats: an ultrastructural analysis. J Bone Miner Res. 1994;9:355-66.

13. Kobayashi Y, Goto S, Tanno T, Yamazaki M, Moriya H. Regional variations in the progression of bone loss in two different mouse osteopenia models. Calcif Tissue Int. 1998;62:426-36.

14. Ferguson VL, Ayers RA, Bateman TA, Simske SJ. Bone development and age-related bone loss in male C57BL/6J mice. Bone. 2003;33:387-98. [OpenAIRE]

15. Turner CH, Hsieh Y-F, Müller R, Bouxsein ML, Baylink DJ, Rosen CJ, et al. Genetic Regulation of Cortical and Trabecular Bone Strength and Microstructure in Inbred Strains of Mice. J Bone Miner Res. 2000;15:1126-31.

16. Weiss A, Arbell I, Steinhagen-Thiessen E, Silbermann M. Structural changes in aging bone: osteopenia in the proximal femurs of female mice. Bone. 1991;12:165-72.

78 references, page 1 of 6
Abstract
La osteoporosis senil o involutiva es un problema de primera magnitud en el mundo desarrollado. Estudios recientes apuntan al aumento del estrés oxidativo asociado al envejecimiento -cronológico o biológico- como un factor importante en su desarrollo. En esta revisión nos centraremos en las alteraciones del tejido óseo con la edad, en el origen del estrés oxidativo y su influencia negativa en el tejido óseo. Finalmente, abordaremos las posibles terapias antiestrés oxidativo que actualmente se encuentran en desarrollo en esta patología. Senile or involutional osteoporosis is a major problem in the developed world. Recent studies point to increased oxidative stres...
Subjects
free text keywords: estrés oxidativo, osteoporosis, envejecimiento, fragilidad, oxidative stress, aging, fragility, lcsh:Medicine, lcsh:R, lcsh:Osteopathy, lcsh:RZ301-397.5
78 references, page 1 of 6

Osteoporos Int. 1992;2:285-9.

Reginster J-Y, Burlet N. Osteoporosis: a still increasing prevalence. Bone. 2006;38:S4-9.

Khosla S, Riggs BL. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am. 2005;34:1015-30, xi. [OpenAIRE]

Van Staa TP, Laan RF, Barton IP, Cohen S, Reid DM, Cooper C. Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum. 2003;48:3224-9.

Diabetes and its complications and their relationship with risk of fractures in type 1 and 2 diabetes. Calcif Tissue Int. 2009;84:45-55.

Miller PD. Bone disease in CKD: a focus on osteoporosis diagnosis and management. Am J Kidney Dis. 2014;64:290-304.

8. Eriksen EF. Cellular mechanisms of bone remodeling. Rev. Endocr. Metab Disord. 2010;11:219-27.

9. Bailey AJ, Knott L. Molecular changes in bone collagen in osteoporosis and osteoarthritis in the elderly. Exp Gerontol. 1999;34:337-51.

10. Wang L, Banu J, McMahan CA, Kalu DN. Male rodent model of age-related bone loss in men. Bone. 2001;29:141-8.

11. Liang CT, Barnes J, Seedor JG, Quartuccio HA, Bolander M, Jeffrey JJ, et al. Impaired bone activity in aged rats: alterations at the cellular and molecular levels. Bone. 1992;13:435-41.

12. Roholl PJ, Blauw E, Zurcher C, Dormans JA, Theuns HM. Evidence for a diminished maturation of preosteoblasts into osteoblasts during aging in rats: an ultrastructural analysis. J Bone Miner Res. 1994;9:355-66.

13. Kobayashi Y, Goto S, Tanno T, Yamazaki M, Moriya H. Regional variations in the progression of bone loss in two different mouse osteopenia models. Calcif Tissue Int. 1998;62:426-36.

14. Ferguson VL, Ayers RA, Bateman TA, Simske SJ. Bone development and age-related bone loss in male C57BL/6J mice. Bone. 2003;33:387-98. [OpenAIRE]

15. Turner CH, Hsieh Y-F, Müller R, Bouxsein ML, Baylink DJ, Rosen CJ, et al. Genetic Regulation of Cortical and Trabecular Bone Strength and Microstructure in Inbred Strains of Mice. J Bone Miner Res. 2000;15:1126-31.

16. Weiss A, Arbell I, Steinhagen-Thiessen E, Silbermann M. Structural changes in aging bone: osteopenia in the proximal femurs of female mice. Bone. 1991;12:165-72.

78 references, page 1 of 6
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