publication . Article . Contribution for newspaper or weekly magazine . 2013

Function of Receptor 1 in uptaking transferrin and its relation to iron deficiency and iron gestational preeclampsia

Beatriz Elena Parra-Sosa;
  • Published: 01 Mar 2013
Abstract
La anemia ferropénica gestacional afecta al 48 % de las mujeres y se asocia con efectos deletéreos para la madre y el feto. Para la captación del hierro de la gestante es necesaria la expresión en el sincitiotrofoblasto de la glicoproteína receptor 1 de transferrina (TfR1). En ensayos celulares, en modelos animales y en humanos la deprivación de hierro se ha asociado a un aumento en la transcripción y expresión del TfR1, que se ha explicado como un mecanismo compensatorio para la captación del hierro a favor del feto. De otra parte, en alteraciones de la gestación como la preeclampsia se espera un aumento en la expresión del TfR1 placentario, sin embargo se ha e...
Subjects
Medical Subject Headings: embryonic structuresreproductive and urinary physiology
free text keywords: metabolismo de hierro, deficiencia de hierro, placenta, receptor de transferrina, preeclampsia, N-glicosilación, iron metabolism, iron deficiency, transferrin receptor, N-glycosylation
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publication . Article . Contribution for newspaper or weekly magazine . 2013

Function of Receptor 1 in uptaking transferrin and its relation to iron deficiency and iron gestational preeclampsia

Beatriz Elena Parra-Sosa;