Role of invariant nkt cells in the anti-viral immune response

Article Spanish OPEN
Román, Alejandro; Rugeles, María Teresa; Montoya, Carlos Julio;
  • Publisher: Facultad de Salud, Universidad del Valle, Cali, Colombia
  • Subject: Alfa-Galactosilceramida | viral infection | VIH | HIV | Células iNKT | alpha-GalactosylCeramide | iNKT cells | Infección viral

Las células T asesinas naturales con receptor de células T invariante y restringidas por la molécula CD1d (iNKT) son un subgrupo de linfocitos con potente actividad inmunorreguladora; su respuesta casi inmediata y la capacidad de producir citoquinas tanto Th1 como Th2 s... View more
  • References (49)
    49 references, page 1 of 5

    1. Fowlkes BJ, Kruisbeek AM, Ton-That H, Weston MA, Coligan JE, Schwartz RH, et al. A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family. Nature 1987;329: 251-254.

    2. Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ, Van Kaer L. NKT cells: What's in a name? Nat Rev Immunol 2004; 4: 231-237.

    3. Exley MA, Koziel MJ. To be or not to be NKT: natural killer T cells in the liver. Hepatology 2004; 40: 1033-1040.

    4. Gumperz JE. Antigen specificity of semi-invariant CD1drestricted T cell receptors: the best of both worlds? Immunol Cell Biol 2004; 82: 285-294.

    5. Fischer K, Scotet E, Niemeyer M, Koebernick H, Zerrahn J, Maillet S, et al. Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells. Proc Natl Acad Sci USA 2004; 101: 10685-10690.

    6. Godfrey DI, Pellicci DG, Smyth MJ. The elusive NKT cell antigen - is the search over? Science 2004; 306: 1687-1689.

    7. Wu DY, Segal NH, Sidobre S, Kronenberg M, Chapman PB. Cross-presentation of disialoganglioside GD3 to natural killer T cells. J Exp Med 2003; 198:173-181.

    8. Spada FM, Koezuka Y, Porcelli SA. CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J Exp Med 1998; 188: 1529-1534.

    9. Giaccone G, Punt CJ, Ando Y, Ruijter R, Nishi N, Peters M, et al. A phase I study of the natural killer T-cell ligand alphagalactosylceramide (KRN7000) in patients with solid tumors. Clin Cancer Res 2002; 8: 3702-3709.

    10. Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ, Baxter AG. NKT cells: facts, functions and fallacies. Immunol Today 2000; 21: 573-583.

  • Metrics
Share - Bookmark