publication . Report . 2017

Incertezas na Abordagem ao Doente com Síndrome de Lynch: A propósito de um Caso Clínico

Campos, Sara; Amaro, Pedro; Cunha, Inês; Fraga, João; Cipriano, Maria Augusta; Tomé, Luís;
Open Access English
  • Published: 01 Oct 2017
  • Publisher: Sociedade Portuguesa de Gastrenterologia
Introduction: Lynch syndrome (LS), the most common hereditary colorectal cancer syndrome, is characterized by mutations in mismatch repair (MMR) genes leading to an increased cancer risk, namely colorectal cancer. Case: In the context of surveillance colonoscopy, a 40-mm flat lesion (0-IIa+b, Paris classification) was identified and submitted to piecemeal mucosal endoscopic resection in a 64-year-old LS patient with an MLH1 germline mutation (262delATC) and two previous segmental resections due to metachronous colorectal cancer. Pathology raised the suspicion of superficial submucosal invasive carcinoma with poor differentiation. Immunochemistry showed heterogen...
free text keywords: Imunohistoquímica, Lynch syndrome, Resseção endoscópica, Síndrome de Lynch, Endoscopic resection, Immunochemistry

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