Eficacia de los antivirales en la parálisis de Bell

Article Spanish OPEN
Vázquez, María Cristina; Sánchez, Nury; Calvo, Judith; Perna, Abayubá;
(2008)
  • Publisher: Sindicato Médico del Uruguay
  • Subject: HERPES VIRUS HUMANO 1 | VALACICLOVIR | PARÁLISIS DE BELL | BELL PALSY | ANTIVIRAL AGENTS | PREDNISONA | HERPESVIRUS 1 HUMAN | PREDNISONE | AGENTES ANTIVIRALES

Introducción: la parálisis de Bell es una afección frecuente que presenta en 15% de los casos una recuperación incompleta. En los últimos años se ha acumulado evidencia del posible rol del virus herpes simple tipo 1 en su etiología. Objetivos: comparar la eficacia de va... View more
  • References (27)
    27 references, page 1 of 3

    Objectives: to compare the efficacy of valacyclovir and prednisone versus prednisone plus placebo. Of 41 patients included in the study, 21 were treated with valacyclovir, 2g a day for seven days, and prednisone; and 19 with prednisone plus placebo, administered orally.

    Clinical controls were carried out at weeks 2, 4, 8 and 12. Patients who had incomplete recoveries were followed studied for six months. Recovery was defined as satisfactory when the score was over 90, using a facial paralysis complex scale (FGS - Facial Grading Scale).

    After six months, recovery was 86.4% in the valacyclovir and prednisone group, and 89.5% in the prednisone plus placebo group (p=0,86). Average recovery time was 70.2 and 71.1 days, respectively (p=0,88).

    Conclusions: our results fail to prove additional ben1. Rowlands S, Hooper R, Hughes R, Burney P. The epide-

    2002; 9(1): 63-7. 2. Grogan PM, Gronseth GS. Practice parameter: Steroids,

    American Academy of Neurology. Neurology 2001; 56: 830-6. 3. Peitersen E. The natural history of Bell's palsy. Amer J Otol

    1982; 4(2): 107-11. 4. McCormick DP. Herpes simplex virus as a cause of Bell's

    palsy. Lancet 1972; 1: 937-9. 5. Murakami S, Mizobuchi M, Nakashiro Y, Doi T, Hato N,

    Inter Med 1996; 124: 27-30. 6. Takasu T, Furuta Y, Sato KC, Fukuda S, Inuyama Y,

    reaction. Acta Otolaryngol 1992; 112(6): 1004-11. 7. Allen D, Dunn L. Aciclovir or valaciclovir for Bell's palsy

  • Metrics
    No metrics available
Share - Bookmark