publication . Article . 2015

Localización de los Receptores Cannabinoides 1 (CB1) en Glándulas Salivales Submandibulares y Sublinguales de Ratones Durante el Desarrollo Postnatal

Hipkaeo, Wiphawi; Watanabe, Masahiko; Kondo, Hisatake;
Open Access English
  • Published: 01 Jun 2015
  • Publisher: Sociedad Chilena de Anatomía
In view of the fact that human marijuana users often show dry mouth symptom, the present study was attempted to examine the localization of CB1, which was originally identified in brain, in the submandibular and sublingual salivary glands of postnatal developing male mice by immunohistochemistry. In submandibular gland, CB1-immunoreactivity was positive in a majority of acinar cells in forms of granular appearance in their apical cytoplasm, while it was negative in the ducts at newborn stage. The immunoreactivity decreased in the acinar cells at P1W and no immunoreactivity was detected in the acinar cells at P3W and thereafter. The immunoreactivity was positive ...
mesheuropmc: stomatognathic system
free text keywords: Glándula submandibular, Sublingual gland, Ratón postnatal, Receptores de cannabinoides 1, Inmunohistoquímica, Glándula sublingual, Cannabinoid receptor 1, Immunohistochemistry, Postnatal mice, Submandibular gland
19 references, page 1 of 2

Buckley, N. E.; Hansson, S.; Harta, G. & Mezey, E. Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the rat. Neuroscience, 82(4):1131-49, 1998.

Busch, L.; Sterin-Borda, L. & Borda, E. Expression and biological effects of CB1 cannabinoid receptor in rat parotid gland. Biochem. Pharmacol., 68(9):1767-74, 2004.

Dall'Aglio, C.; Mercati, F.; Pascucci, L.; Boiti, C.; Pedini, V. & Ceccarelli, P. Immunohistochemical localization of CB1 receptor in canine salivary glands. Vet. Res. Commun., 34 (Suppl. 1):S9-12, 2010.

Denny, P. C.; Chai, Y.; Pimprapaiporn, W. & Denny, P. A. Three-dimensional reconstruction of adult female mouse submandibular gland secretory structures. Anat. Rec., 226(4):489-500, 1990.

Freund, T. F.; Katona, I. & Piomelli, D. Role of endogenous cannabinoids in synaptic signaling. Physiol. Rev., 83(3):1017-66, 2003. [OpenAIRE]

Kano, M.; Ohno-Shosaku, T.; Hashimotodani, Y.; Uchigashima, M. & Watanabe, M. Endocannabinoid-mediated control of synaptic transmission. Physiol. Rev., 89(1):309-80, 2009.

Kopach, O.; Vats, J.; Netsyk, O.; Voitenko, N.; Irving, A. & Fedirko, N. Cannabinoid receptors in submandibular acinar cells: functional coupling between saliva fluid and electrolytes secretion and Ca2+ signalling. J. Cell. Sci., 125 (Pt. 8):1884-95, 2011.

Matsuda, L. A. Molecular aspects of cannabinoid receptors. Crit. Rev. Neurobiol., 11(2-3):143-66, 1997.

Matsuda, L. A.; Lolait, S. J.; Brownstein, M. J.; Young, A. C. & Bonner, T. I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature, 346(6284):561-4, 1990.

Navarrete, M. & Araque, A. Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes. Neuron, 68(1):113- 26, 2010. [OpenAIRE]

Osborne, K. D.; Lee, W.; Malarkey, E. B.; Irving, A. J. & Parpura, V. Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes. A. S. N. Neuro., 1(5):pii:AN20090040, 2009.

Pertwee, R. G. Cannabinoids and the gastrointestinal tract. Gut, 48(6):859- 67, 2001.

Prestifilippo, J. P.; Fernández-Solari, J.; de la Cal, C.; Iribarne, M.; Suburo, A. M.; Rettori, V; McCann, S. M. & Elverdin, J. C. Inhibition of salivary secretion by activation of cannabinoid receptors. Exp. Biol. Med. (Maywood), 231(8):1421-9, 2006.

Sanger, G. J. Endocannabinoids and the gastrointestinal tract: what are the key questions? Br. J. Pharmacol., 152(5):663-70, 2007. [OpenAIRE]

Uchigashima, M.; Narushima, M.; Fukaya, M. Katona, I.; Kano, M. & Watanabe, M. Subcellular arrangement of molecules for 2- arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. J. Neurosci., 27(14):3663-76, 2007. [OpenAIRE]

19 references, page 1 of 2
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue