publication . Article . 2018

Las Células Madre Mesenquimales Reducen la Masa Ventricular Izquierda en Ratas con Miocardiopatía Inducida por Doxorrubicina

Haydardedeoglu, Ali Evren; Boztok Özgermen, Deva Basak; Yavuz, Orhan;
Open Access English
  • Published: 01 Mar 2018
  • Publisher: Sociedad Chilena de Anatomía
Abstract
SUMMARY: Doxorubicin is a drug that used by a majority in the treatment of carcinomas. The most obvious known side effect is cardiomyopathy. Many studies have been carried out to eliminate side effects of the doxorubicin, and stem cell studies have been added in recent years. In this study, it was aimed to investigate fetal-derived mesenchymal stem cells (F-MSCs) treatment of doxorubicininduced cardiomyopathy by morphological methods. A total of 24 rats which were divided into three separate groups (Control, sham, treatment), each consisting of 8 male rats were used. In sham and treatment group, Adriamycin was administered in a single dose by tail injection to p...
Subjects
free text keywords: Morfometría, Adriamicina, Pluripotent stem cell, Adriamycin, Morphometry, Célula madre pluripotente, Corazón, Heart
Related Organizations
25 references, page 1 of 2

Andrades, J. A.; Claros, S.; Jiménez-Palomo, P.; López-Puerta, J. M.; Zamora-Navas, P.; Guerado, E.; Monleón, M.; Araque, M. C. & Becerra, J. Skeletal regeneration by mesenchymal stem cells: What else? In: Eberli, D. (Ed.). Regenerative Medicine and Tissue Engineering - Cells and Biomaterials. London, InTech, 2011. pp.107-44. [OpenAIRE]

Angert, D.; Berretta, R. M.; Kubo, H.; Zhang, H.; Chen, X.; Wang, W.; Ogorek, B.; Barbe, M. & Houser, S. R. Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells. Circ. Res., 108(10):1226-37, 2011.

Devereux, R. B. & Reichek, N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation, 55(4):613-8, 1977.

Dreesen, O. & Brivanlou, A. H. Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev., 3(1):7-17, 2007.

Erer, H. & Kiran, M. M. Veterinary Oncology. Konya, Bahcivanlar Publishers, 2005

Foppa, M.; Duncan, B. B. & Rohde, L. E. Echocardiography-based left ventricular mass estimation. How should we define hypertrophy? Cardiovasc. Ultrasound, 3:17, 2005. [OpenAIRE]

Friedenstein, A. J.; Gorskaja, J. F. & Kalugina, N. N. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp. Hematol., 4(5):267-74, 1976.

Garbade, J.; Schubert, A.; Barten, M.J.; Aupperle, H.; Arsalan, M.; Borger, M.A.; Jacobs, S.; Dhein, S. & Mohr, F.W. Stem cell transplantation modulates mRNA gene expression profile in doxorubicin-induced cardiomyopathy. J. Stem Cells, 3:235-44, 2008.

Gava, F. N.; Zacché, E.; Ortiz, E. M.; Champion, T.; Bandarra, M. B.; Vasconcelos, R. O.; Barbosa, J. C. & Camacho, A. A. Doxorubicin induced dilated cardiomyopathy in a rabbit model: an update. Res. Vet. Sci., 94(1):115-21, 2013.

Ichim, T. E.; Solano, F.; Brenes, R.; Glenn, E.; Chang, J.; Chan, K. & Riordan, N. H. Placental mesenchymal and cord blood stem cell therapy for dilated cardiomyopathy. Reprod. Biomed. Online, 16(6):898-905, 2008.

Kasama, S.; Toyama, T.; Hatori, T.; Sumino, H.; Kumakura, H.; Takayama, Y.; Ichikawa, S.; Suzuki, T. & Kurabayashi, M. Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol. Eur. Heart J., 28(8):989-95, 2007. [OpenAIRE]

Kershaw, O.; Heblinski, N.; Lotz, F.; Dirsch, O. & Gruber, A. D. Diagnostic value of morphometry in feline hypertrophic cardiomyopathy. J. Comp. Pathol., 147(1):73-83, 2012.

Lushnikova, E. L.; Klinnikova, M. G.; Molodykh, O. P. & Nepomnyashchikh, L. M. Morphological manifestations of heart remodeling in anthracyclineinduced dilated cardiomyopathy. Bull. Exp. Biol. Med., 138(6):607-12, 2004.

Momiyama, Y.; Mitamura, H. & Kimura, M. ECG characteristics of dilated cardiomyopathy. J. Electrocardiol., 27(4):323-8, 1994.

Nagaya, N.; Kangawa, K.; Itoh, T.; Iwase, T.; Murakami, S.; Miyahara, Y.; Fujii, T.; Uematsu, M.; Ohgushi, H.; Yamagishi, M.; Tokudome, T.; Mori, H.; Miyatake, K. & Kitamura, S. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation, 112(8):1128-35, 2005.

25 references, page 1 of 2
Similar Outcomes
Abstract
SUMMARY: Doxorubicin is a drug that used by a majority in the treatment of carcinomas. The most obvious known side effect is cardiomyopathy. Many studies have been carried out to eliminate side effects of the doxorubicin, and stem cell studies have been added in recent years. In this study, it was aimed to investigate fetal-derived mesenchymal stem cells (F-MSCs) treatment of doxorubicininduced cardiomyopathy by morphological methods. A total of 24 rats which were divided into three separate groups (Control, sham, treatment), each consisting of 8 male rats were used. In sham and treatment group, Adriamycin was administered in a single dose by tail injection to p...
Subjects
free text keywords: Morfometría, Adriamicina, Pluripotent stem cell, Adriamycin, Morphometry, Célula madre pluripotente, Corazón, Heart
Related Organizations
25 references, page 1 of 2

Andrades, J. A.; Claros, S.; Jiménez-Palomo, P.; López-Puerta, J. M.; Zamora-Navas, P.; Guerado, E.; Monleón, M.; Araque, M. C. & Becerra, J. Skeletal regeneration by mesenchymal stem cells: What else? In: Eberli, D. (Ed.). Regenerative Medicine and Tissue Engineering - Cells and Biomaterials. London, InTech, 2011. pp.107-44. [OpenAIRE]

Angert, D.; Berretta, R. M.; Kubo, H.; Zhang, H.; Chen, X.; Wang, W.; Ogorek, B.; Barbe, M. & Houser, S. R. Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells. Circ. Res., 108(10):1226-37, 2011.

Devereux, R. B. & Reichek, N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation, 55(4):613-8, 1977.

Dreesen, O. & Brivanlou, A. H. Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev., 3(1):7-17, 2007.

Erer, H. & Kiran, M. M. Veterinary Oncology. Konya, Bahcivanlar Publishers, 2005

Foppa, M.; Duncan, B. B. & Rohde, L. E. Echocardiography-based left ventricular mass estimation. How should we define hypertrophy? Cardiovasc. Ultrasound, 3:17, 2005. [OpenAIRE]

Friedenstein, A. J.; Gorskaja, J. F. & Kalugina, N. N. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp. Hematol., 4(5):267-74, 1976.

Garbade, J.; Schubert, A.; Barten, M.J.; Aupperle, H.; Arsalan, M.; Borger, M.A.; Jacobs, S.; Dhein, S. & Mohr, F.W. Stem cell transplantation modulates mRNA gene expression profile in doxorubicin-induced cardiomyopathy. J. Stem Cells, 3:235-44, 2008.

Gava, F. N.; Zacché, E.; Ortiz, E. M.; Champion, T.; Bandarra, M. B.; Vasconcelos, R. O.; Barbosa, J. C. & Camacho, A. A. Doxorubicin induced dilated cardiomyopathy in a rabbit model: an update. Res. Vet. Sci., 94(1):115-21, 2013.

Ichim, T. E.; Solano, F.; Brenes, R.; Glenn, E.; Chang, J.; Chan, K. & Riordan, N. H. Placental mesenchymal and cord blood stem cell therapy for dilated cardiomyopathy. Reprod. Biomed. Online, 16(6):898-905, 2008.

Kasama, S.; Toyama, T.; Hatori, T.; Sumino, H.; Kumakura, H.; Takayama, Y.; Ichikawa, S.; Suzuki, T. & Kurabayashi, M. Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol. Eur. Heart J., 28(8):989-95, 2007. [OpenAIRE]

Kershaw, O.; Heblinski, N.; Lotz, F.; Dirsch, O. & Gruber, A. D. Diagnostic value of morphometry in feline hypertrophic cardiomyopathy. J. Comp. Pathol., 147(1):73-83, 2012.

Lushnikova, E. L.; Klinnikova, M. G.; Molodykh, O. P. & Nepomnyashchikh, L. M. Morphological manifestations of heart remodeling in anthracyclineinduced dilated cardiomyopathy. Bull. Exp. Biol. Med., 138(6):607-12, 2004.

Momiyama, Y.; Mitamura, H. & Kimura, M. ECG characteristics of dilated cardiomyopathy. J. Electrocardiol., 27(4):323-8, 1994.

Nagaya, N.; Kangawa, K.; Itoh, T.; Iwase, T.; Murakami, S.; Miyahara, Y.; Fujii, T.; Uematsu, M.; Ohgushi, H.; Yamagishi, M.; Tokudome, T.; Mori, H.; Miyatake, K. & Kitamura, S. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation, 112(8):1128-35, 2005.

25 references, page 1 of 2
Similar Outcomes
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