Efficient 'One Pot' Nitro Reduction-Protection of γ-Nitro Aliphatic Methyl Esters

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Díaz-Coutiño, Francisco D.; Escalante, Jaime;
  • Publisher: Sociedad Química de México A.C.
  • Subject: γ-nitro reducción | Reacción 'One-pot' | 'One-pot' reaction | γ-nitro reduction | N-Boc-amino protection | N-Boc-amino protección

A simple and efficient protocol has been developed for the direct conversion of γ-nitro aliphatic methyl esters to N-(tert-butoxycarbonyl)amine methyl esters using NH4+HCO2- and Pd/C in the presence of (Boc)2O. There was a significant decrease in the reaction time under... View more
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