publication . Article . 2010

Anti-HLA antibodies and acute renal graft rejection in children

Galeas, Rubén Arturo; Gomezchico-Velasco, Rebeca; Valverde, Saúl; Ramón-García, Guillermo; Velásquez-Jones, Luis; Romero-Navarro, Benjamín; Hernández, Ana María; Vargas, Arindal; Leo, Claudia de; Medeiros, Mara;
Open Access Spanish
  • Published: 01 Dec 2010
  • Publisher: Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez
Abstract
Introducción. A pesar de que las nuevas terapias inmunosupresoras han mejorado notablemente la evolución clínica de los trasplantes renales, los rechazos agudo y crónico siguen limitando la sobrevida a largo plazo del injerto. En base a lo anterior, el objetivo de este estudio fue determinar la presencia de anticuerpos séricos contra antígenos de histocompatibilidad (HLA) clase I y clase II en niños con rechazo agudo del injerto renal. Métodos. Se realizó un estudio clínico prospectivo en pacientes con trasplante renal que presentaron rechazo agudo del injerto. Se les tomó muestra de suero al momento de la biopsia renal, misma que fue utilizada para la detección...
Subjects
free text keywords: rechazo mediado por anticuerpos, rechazo celular, rituximab, plasmaféresis, globulina intravenosa, metilprednisolona, antibody mediated rejection, plasmapheresis, intravenous inmmunoglobulin, metilprednisolone, cellular rejection
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