publication . Article . 2014

MALDI imaging mass spectrometry: Discrimination of pathophysiological regions in traumatized skeletal muscle by characteristic peptide signatures

Oliver Klein; Kristin Strohschein; Grit Nebrich; Janina Oetjen; Dennis Trede; Herbert Thiele; Theodore Alexandrov; Patrick Giavalisco; Georg N. Duda; Philipp von Roth; ...
Closed Access English
  • Published: 21 Aug 2014
  • Country: Germany
Abstract
Due to formation of fibrosis and the loss of contractile muscle tissue, severe muscle injuries often result in insufficient healing marked by a significant reduction of muscle force and motor activity. Our previous studies demonstrated that the local transplantation of mesenchymal stromal cells into an injured skeletal muscle of the rat improves the functional outcome of the healing process. Since, due to the lack of sufficient markers, the accurate discrimination of pathophysiological regions in injured skeletal muscle is inadequate, underlying mechanisms of the beneficial effects of mesenchymal stromal cell transplantation on primary trauma and trauma adjacent...
Subjects
free text keywords: Biochemistry, Molecular Biology, MALDI imaging, Biology, Pathophysiology, Skeletal muscle, medicine.anatomical_structure, medicine, Mass spectrometry, Peptide, chemistry.chemical_classification, chemistry
Funded by
EC| 3D-MASSOMICS
Project
3D-MASSOMICS
Statistical methods for 3D imaging mass spectrometry in proteomics and metabolomics
  • Funder: European Commission (EC)
  • Project Code: 305259
  • Funding stream: FP7 | SP1 | HEALTH
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2014

MALDI imaging mass spectrometry: Discrimination of pathophysiological regions in traumatized skeletal muscle by characteristic peptide signatures

Oliver Klein; Kristin Strohschein; Grit Nebrich; Janina Oetjen; Dennis Trede; Herbert Thiele; Theodore Alexandrov; Patrick Giavalisco; Georg N. Duda; Philipp von Roth; ...