publication . Article . 2012

Diminuição dos níveis de BDNF em amígdala e hipocampo após a administração intracerebroventricular de ouabaína

Jornada, Luciano K.; Valvassori, Samira S.; Resende, Wilson R.; Moretti, Morgana; Ferreira, Camila L.; Fries, Gabriel R.; Kapczinski, Flavio; Quevedo, João;
Open Access English
  • Published: 01 Jan 2012
  • Publisher: Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
Abstract
OBJECTIVE: The present study aims to investigate the effects of ouabain intracerebroventricular injection on BDNF levels in the amygdala and hippocampus of Wistar rats. METHODS: Animals received a single intracerebroventricular injection of ouabain (10-3 and 10-2 M) or artificial cerebrospinal fluid and immediately, 1h, 24h, or seven days after injection, BDNF levels were measured in the rat's amygdala and hippocampus by sandwich-ELISA (n = 8 animals per group). RESULTS: When evaluated immediately, 3h, or 24h after injection, ouabain in doses of 10-2 and 10-3 M does not alter BDNF levels in the amygdala and hippocampus. However, when evaluated seven days after i...
Subjects
Medical Subject Headings: nervous system
free text keywords: BDNF; mania; Na/K ATPase; ouabain, BDNF; mania; Na/K ATPase; ouabaína, ouabain, BDNF, mania, Na/K ATPase, ouabaína, Psychiatry, RC435-571, Psychology, Molecular biology, medicine.medical_specialty, medicine
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2012

Diminuição dos níveis de BDNF em amígdala e hipocampo após a administração intracerebroventricular de ouabaína

Jornada, Luciano K.; Valvassori, Samira S.; Resende, Wilson R.; Moretti, Morgana; Ferreira, Camila L.; Fries, Gabriel R.; Kapczinski, Flavio; Quevedo, João;