publication . Article . 2013

The protective effect of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell membrane oxidative stress in rats with streptozotocin-induced diabetes

Mohamed, Jamaludin; Shing, Saw Wuan; Idris, Muhd Hanis Md; Budin, Siti Balkis; Zainalabidin, Satirah;
Open Access
  • Published: 01 Oct 2013 Journal: Clinics, volume 68, pages 1,358-1,363 (issn: 1807-5932, Copyright policy)
  • Publisher: Fundacao Faculdade de Medicina
OBJECTIVES: The aim of this study was to investigate the protective effects of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell (RBC) membrane oxidative stress in rats with streptozotocin-induced diabetes. METHODS: Forty male Sprague-Dawley rats weighing 230-250 g were randomly divided into four groups (n = 10 rats each): control group (N), roselle-treated control group, diabetic group, and roselle-treated diabetic group. Roselle was administered by force-feeding with aqueous extracts of roselle (100 mg/kg body weight) for 28 days. RESULTS: The results demonstrated that the malondialdehyde levels of the red blood cell membranes ...
free text keywords: Roselle, Red Blood Cell Membrane, General Medicine, Streptozotocin, medicine.drug, medicine, Surgery, medicine.medical_specialty, Erythrocyte fragility, Red blood cell, medicine.anatomical_structure, Superoxide dismutase, biology.protein, biology, Diabetes mellitus, medicine.disease, Malondialdehyde, chemistry.chemical_compound, chemistry, Hibiscus sabdariffa, Oxidative stress, medicine.disease_cause, business.industry, business, Medicine (General), R5-920, Basic Research
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36 references, page 1 of 3

Martín-Gallán, P, Carrascosa, A, Gussinyé, M, Domínguez, C. Biomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complications. Free Radic Biol Med. 2003; 34(12): 1563-74 [PubMed]

Wolff, SP, Dean, RT. Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation' in diabetes. Biochem J. 1987; 245: 243-50 [OpenAIRE] [PubMed]

Chung, SSM, Ho, ECM, Lam, KSL, Chung, SK. Contribution of polyol pathway to diabetes-induced oxidative stress. J Am Soc Nephrol. 2003; 14(Suppl. 3): S233-6 [PubMed]

Wolff, SP, Jiang, ZY, Hunt, JV. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic Biol Med. 1991; 10(5): 339-52 [PubMed]

Rizvi, SI, Zaid, MA, Anis, R, Mishra, N. Protective role of tea catechins against oxidation-induced damage of type 2 diabetic erythrocytes. Clin Exp Pharmacol Physiol. 2005; 32(1-2): 70-5 [PubMed]

Draper, HH, Hadley, M, Packer, L, Glazer, A N. Malondialdehyde determination as index of lipid peroxidation. Methods in Enzymology. 1990; Vol. 186: pp421-30

Dalle-Donne, I, Rossi, R, Giustarini, D, Milzani, A, Colombo, R. Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta. 2003; 329(1-2): 23-38 [PubMed]

Jain, SK. Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells. J Biol Chem. 1989; 264(35): 21340-5 [PubMed]

Ali, BH, Wabel, NA, Blunden, G. Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: A review. Phytother Res. 2005; 19(5): 369-75 [PubMed]

Tsai, P-J, McIntosh, J, Pearce, P, Camden, B, Jordan, BR. Anthocyanin and antioxidant capacity in Roselle (Hibiscus sabdariffa L.) extract. Food Res Int. 2002; 35(4): 351-6

Farombi, EO, Ige, OO. Hypolipidemic and antioxidant effects of ethanolic extract from dried calyx of Hibiscus sabdariffa in alloxan-induced diabetic rats. Fundam Clin Pharmacol. 2007; 21: 601-9 [OpenAIRE] [PubMed]

Osman, M, Golam, F, Saberi, S, Majid, NA, Nagoor, NH, Zulqarnain, M. Morpho-agronomic analysis of three roselle (Hibiscus sabdariffa L.) mutants in tropical Malaysia. Aust J Crop Sci. 2011; 5(10): 1150-6

Wu, KK, Huan, Y, Enna, S J, Williams, M, Frechette, R, Kenakin, T, McGonigle, P, Ruggeri, B. Streptozotocin-induced diabetic models in mice and rats. 2008: pp5.47.1-5.47.14

Jung, CH, Zhou, S, Ding, GX, Kim, JH, Hong, MH, Shin Y-Cet, al. Antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem. 2006; 70(10): 2556-9 [PubMed]

Idris, MHM, Budin, SB, Osman, M, Mohamed, J. Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats. EXCLI Journal. 2012; 11: 659-69 [OpenAIRE]

36 references, page 1 of 3
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