publication . Article . 2013

The protective effect of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell membrane oxidative stress in rats with streptozotocin-induced diabetes

Mohamed, Jamaludin; Shing, Saw Wuan; Idris, Muhd Hanis Md; Budin, Siti Balkis; Zainalabidin, Satirah;
Open Access
  • Published: 01 Oct 2013 Journal: Clinics, volume 68, pages 1,358-1,363 (issn: 1807-5932, Copyright policy)
  • Publisher: Fundacao Faculdade de Medicina
Abstract
OBJECTIVES: The aim of this study was to investigate the protective effects of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell (RBC) membrane oxidative stress in rats with streptozotocin-induced diabetes. METHODS: Forty male Sprague-Dawley rats weighing 230-250 g were randomly divided into four groups (n = 10 rats each): control group (N), roselle-treated control group, diabetic group, and roselle-treated diabetic group. Roselle was administered by force-feeding with aqueous extracts of roselle (100 mg/kg body weight) for 28 days. RESULTS: The results demonstrated that the malondialdehyde levels of the red blood cell membranes ...
Subjects
free text keywords: Roselle, Red Blood Cell Membrane, General Medicine, Streptozotocin, medicine.drug, medicine, Surgery, medicine.medical_specialty, Erythrocyte fragility, Red blood cell, medicine.anatomical_structure, Superoxide dismutase, biology.protein, biology, Diabetes mellitus, medicine.disease, Malondialdehyde, chemistry.chemical_compound, chemistry, Hibiscus sabdariffa, Oxidative stress, medicine.disease_cause, business.industry, business, Medicine (General), R5-920, Basic Research
Related Organizations
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