publication . Article . 2012

Biginelli and Mannich multicomponent reactions in the undergraduate organic chemistry laboratory: a didactic approach to green chemistry principles

Marcelo V. Marques; Tula B. Bisol; Marcus M. Sá;
Open Access English
  • Published: 01 Jan 2012 Journal: Química Nova, volume 35, issue 8, pages 1,696-1,699 (issn: 1678-7064, Copyright policy)
  • Publisher: Sociedade Brasileira de Química
Abstract
The introduction of Mannich and Biginelli multicomponent reactions in a practical Organic Chemistry course is presented in this article. Procedures described in the literature were adapted for use under the simple conditions available in undergraduate laboratories and were selected on the basis of Green Chemistry principles and practicality of synthesis. The reactions are easy to carry out and all products are readily isolated as crystalline solids with yields ranging from moderate to high.
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free text keywords: Mannich reaction, Biginelli reaction, Green Chemistry, General Chemistry, lcsh:Chemistry, lcsh:QD1-999, Chemistry, Organic chemistry, Stereochemistry
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