publication . Article . Other literature type . 2018

Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats.

Sylvio Claudio Neto; Ellen Conceição; Patricia Lisboa; Egberto Moura; Manhaes AC;
Open Access
  • Published: 01 Apr 2018 Journal: Brazilian Journal of Medical and Biological Research, volume 51 (issn: 0100-879X, eissn: 1414-431X, Copyright policy)
  • Publisher: FapUNIFESP (SciELO)
Abstract
: Maternal smoking is a risk factor for progeny obesity. We have previously shown, in a rat model of neonatal tobacco smoke exposure, a mild increase in food intake and a considerable increase in visceral adiposity in the adult offspring. Males also had secondary hyperthyroidism, while females had only higher T4. Since brown adipose tissue (BAT) hypofunction is related to obesity, here we tested the hypothesis that higher levels of thyroid hormones are not functional in BAT, suggesting a lower metabolic rate. We evaluated autonomic nerve activity in BAT and its function in adult rats that were exposed to tobacco smoke during lactation. At birth, litters were adj...
Subjects
free text keywords: General Pharmacology, Toxicology and Pharmaceutics, Immunology, Biophysics, Cell Biology, Biochemistry, Physiology, General Neuroscience, General Medicine, Research Articles, Tobacco smoke, Suckling period, Developmental plasticity, Obesity, Autonomic function, Medicine (General), R5-920, Biology (General), QH301-705.5
36 references, page 1 of 3

Barker, DJ. The origins of the developmental origins theory. J Intern Med. 2007; 261: 412-417 [OpenAIRE] [PubMed] [DOI]

Barker, DJ. The developmental origins of adult disease. Eur J Epidemiol. 2003; 18: 733-736 [OpenAIRE] [PubMed] [DOI]

Gluckman, PD, Hanson, MA, Buklijas, T. A conceptual frame work for the developmental origins of health and disease. J Dev Orig Health Dis. 2010; 1: 6-18 [PubMed] [DOI]

Lisboa, PC, de Oliveira, E, de Moura, EG. Obesity and endocrine dysfunction programmed by maternal smoking in pregnancy and lactation. Front Physiol. 2012; 3: 437 [OpenAIRE] [PubMed] [DOI]

Oken, E, Levitan, EB, Gillman, MW. Maternal smoking during pregnancy and child overweight, systematic review and meta-analysis. Int J Obes. 2008; 32: 201-210 [OpenAIRE] [DOI]

Oliveira, E, Moura, E, Santos-Silva, A, Fagundes, A, Rios, A, Abreu-Villaca, Y. Short and long-term effects of maternal nicotine exposure during lactation on body adiposity, lipid profile and thyroid function of rat offspring. J Endocrinol. 2009; 202: 397-405 [PubMed] [DOI]

Santos-Silva, AP, Oliveira, E, Pinheiro, CR, Santana, AC, Nascimento-Saba, CC, Abreu-Villaça, Y. Endocrine effects of tobacco smoke exposure during lactation in weaned and adult male offspring. J Endocrinol. 2013; 218: 13-24 [PubMed] [DOI]

Pinheiro, CR, Moura, EG, Manhães, AC, Fraga, MC, Claudio-Neto, S, Abreu-Villaça, Y. Concurrent maternal and pup postnatal tobacco smoke exposure in wistar rats changes food preference and dopaminergic reward system parameters in the adult male offspring. Neuroscience. 2015; 301: 178-192 [OpenAIRE] [PubMed] [DOI]

Lisboa, PC, Soares, PN, Peixoto, TC, Carvalho, JC, Calvino, C, Rodrigues, VST. Effects of cigarette smoke exposure during suckling on food intake, fat mass, hormones, and biochemical profile of young and adult female rats. Endocrine. 2017; 57: 60-71 [OpenAIRE] [PubMed] [DOI]

Fenzl, A, Kiefer, FW. Brown adipose tissue and thermogenesis. Horm Mol Biol Clin Investg. 2014; 19: 25-37 [OpenAIRE] [DOI]

Park, A, Kim, WK, Bae, KH. Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells. World J Stem Cells. 2014; 6: 33-42 [OpenAIRE] [PubMed] [DOI]

Oelkrug, R, Polymeropoulos, ET, Jastroch, M. Brown adipose tissue: physiological function and evolutionary significance. J Comp Physiol B. 2015; 85: 587-606 [OpenAIRE] [DOI]

Collins, S. β Adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure. Front Endocrinol. 2011; 2: 102 [OpenAIRE] [DOI]

Martínez-Sánchez, N, Alvarez, CV, Ferno, J, Nogueiras, R, Diéguez, C, López, M. Hypothalamic effects of thyroid hormones on metabolism. Best Pract Res Clin Endocrinol Metab. 2014; 5: 703-12 [OpenAIRE] [DOI]

Bianco, AC, Silva, JE. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest. 1987; 79: 295-300 [OpenAIRE] [PubMed] [DOI]

36 references, page 1 of 3
Supplementary Outcomes
Abstract
: Maternal smoking is a risk factor for progeny obesity. We have previously shown, in a rat model of neonatal tobacco smoke exposure, a mild increase in food intake and a considerable increase in visceral adiposity in the adult offspring. Males also had secondary hyperthyroidism, while females had only higher T4. Since brown adipose tissue (BAT) hypofunction is related to obesity, here we tested the hypothesis that higher levels of thyroid hormones are not functional in BAT, suggesting a lower metabolic rate. We evaluated autonomic nerve activity in BAT and its function in adult rats that were exposed to tobacco smoke during lactation. At birth, litters were adj...
Subjects
free text keywords: General Pharmacology, Toxicology and Pharmaceutics, Immunology, Biophysics, Cell Biology, Biochemistry, Physiology, General Neuroscience, General Medicine, Research Articles, Tobacco smoke, Suckling period, Developmental plasticity, Obesity, Autonomic function, Medicine (General), R5-920, Biology (General), QH301-705.5
36 references, page 1 of 3

Barker, DJ. The origins of the developmental origins theory. J Intern Med. 2007; 261: 412-417 [OpenAIRE] [PubMed] [DOI]

Barker, DJ. The developmental origins of adult disease. Eur J Epidemiol. 2003; 18: 733-736 [OpenAIRE] [PubMed] [DOI]

Gluckman, PD, Hanson, MA, Buklijas, T. A conceptual frame work for the developmental origins of health and disease. J Dev Orig Health Dis. 2010; 1: 6-18 [PubMed] [DOI]

Lisboa, PC, de Oliveira, E, de Moura, EG. Obesity and endocrine dysfunction programmed by maternal smoking in pregnancy and lactation. Front Physiol. 2012; 3: 437 [OpenAIRE] [PubMed] [DOI]

Oken, E, Levitan, EB, Gillman, MW. Maternal smoking during pregnancy and child overweight, systematic review and meta-analysis. Int J Obes. 2008; 32: 201-210 [OpenAIRE] [DOI]

Oliveira, E, Moura, E, Santos-Silva, A, Fagundes, A, Rios, A, Abreu-Villaca, Y. Short and long-term effects of maternal nicotine exposure during lactation on body adiposity, lipid profile and thyroid function of rat offspring. J Endocrinol. 2009; 202: 397-405 [PubMed] [DOI]

Santos-Silva, AP, Oliveira, E, Pinheiro, CR, Santana, AC, Nascimento-Saba, CC, Abreu-Villaça, Y. Endocrine effects of tobacco smoke exposure during lactation in weaned and adult male offspring. J Endocrinol. 2013; 218: 13-24 [PubMed] [DOI]

Pinheiro, CR, Moura, EG, Manhães, AC, Fraga, MC, Claudio-Neto, S, Abreu-Villaça, Y. Concurrent maternal and pup postnatal tobacco smoke exposure in wistar rats changes food preference and dopaminergic reward system parameters in the adult male offspring. Neuroscience. 2015; 301: 178-192 [OpenAIRE] [PubMed] [DOI]

Lisboa, PC, Soares, PN, Peixoto, TC, Carvalho, JC, Calvino, C, Rodrigues, VST. Effects of cigarette smoke exposure during suckling on food intake, fat mass, hormones, and biochemical profile of young and adult female rats. Endocrine. 2017; 57: 60-71 [OpenAIRE] [PubMed] [DOI]

Fenzl, A, Kiefer, FW. Brown adipose tissue and thermogenesis. Horm Mol Biol Clin Investg. 2014; 19: 25-37 [OpenAIRE] [DOI]

Park, A, Kim, WK, Bae, KH. Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells. World J Stem Cells. 2014; 6: 33-42 [OpenAIRE] [PubMed] [DOI]

Oelkrug, R, Polymeropoulos, ET, Jastroch, M. Brown adipose tissue: physiological function and evolutionary significance. J Comp Physiol B. 2015; 85: 587-606 [OpenAIRE] [DOI]

Collins, S. β Adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure. Front Endocrinol. 2011; 2: 102 [OpenAIRE] [DOI]

Martínez-Sánchez, N, Alvarez, CV, Ferno, J, Nogueiras, R, Diéguez, C, López, M. Hypothalamic effects of thyroid hormones on metabolism. Best Pract Res Clin Endocrinol Metab. 2014; 5: 703-12 [OpenAIRE] [DOI]

Bianco, AC, Silva, JE. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest. 1987; 79: 295-300 [OpenAIRE] [PubMed] [DOI]

36 references, page 1 of 3
Supplementary Outcomes
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