publication . Doctoral thesis . 2013

Bestimmung der Dynamik von Tumorhypoxie unter Bestrahlung mittels biologischer Bildgebungsverfahren in einem xenograft Tumormausmodell

Maftei, Constantin Alin;
Open Access English
  • Published: 29 Apr 2013
  • Publisher: Technical University of Munich
  • Country: Germany
Abstract
Background: Chronic, acute and hypoxemic hypoxia can lead to resistance to radiation therapy. The purpose of this thesis was to shed light on the role of these three hypoxia subtypes in radiotherapy. Methods: The amount of total hypoxia and hypoxia subtypes were assessed ex-vivo in xenograft tumors via (immuno-)fluorescence and H&E staining. For the non-invasive detection of hypoxia, tumor-bearing mice were injected with 18F-FMISO and underwent a dynamic PET/CT scan. The hypoxic fraction was quantified using the mathematical Wang Model. Results and Conclusions: Total hypoxia was non-homogeneously distributed from the apical to the basal part of the tumors. Chron...
Subjects
free text keywords: Naturwissenschaften, ddc:500
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