publication . Article . 2016

Chronic Porcine Two-Hit Model with Hemorrhagic Shock and textitPseudomonas aeruginosa Sepsis

B. Eissner; K. Matz; A. Smorodchenko; A. Röschmann; B.U. v. Specht;
Open Access
  • Published: 01 Jul 2016
  • Publisher: S. Karger AG
Abstract
Background: Sepsis is still a major cause of death despite well-developed therapeutical strategies such as antibiotics and supportive medication. The aim of this study was to characterize the long-term effects of a two-hit porcine sepsis model with a hemorrhagic shock as ‘first hit’ followed by a Pseudomonas aeruginosa infusion as ‘second hit’. Materials and Methods: Twelve juvenile healthy pigs were anesthetized and hemodynamically monitored. The two-hit group (n = 6) underwent a hemorrhagic shock with a 50% reduction of the mean arterial pressure and/or cardiac index for 45 min, followed by resuscitation, while the control group (n = 6) received no pretreatmen...
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free text keywords: Two-hit model;Sepsis;Hemorrhagic shock;<italic>Pseudomonas aeruginosa</italic>;Pig, ddc:, Sepsis, medicine.disease, medicine, Surgery, medicine.medical_specialty, Resuscitation, Cardiac index, Pseudomonas aeruginosa, medicine.disease_cause, Vascular resistance, medicine.anatomical_structure, Vascular disease, business.industry, business, APACHE II, Mean arterial pressure, Anesthesia
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