publication . Doctoral thesis . 2015

Der Naturstoff Acivicin als Werkzeug für ABPP und die Aktivität von Serin-Hydrolasen in Uterusmyomen

Kreuzer, Johannes;
Open Access English
  • Published: 27 May 2015
  • Publisher: Technical University of Munich
  • Country: Germany
Abstract
The target proteins of acivicin and structure derived probes in tumor cells were identified using activity-based protein profiling. The target proteins were further characterized and their relation to the antitumor activity of acivicin pointed out. In a further project, the activity of serine hydrolases in myoma and myometrium was examined from tissue samples. This revealed a different activity of mast cell proteases. Mittels Activity-based Protein Profiling wurde eine Identifikation der Zielproteine des Naturstoffs Acivicin und von seiner Struktur abgeleiteten Sonden in Tumorzellen durchgeführt. Die gefundenen Zielproteine wurden weiter charakterisiert und eine...
Subjects
free text keywords: Chemie, ddc:540
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Doctoral thesis . 2015
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