publication . Doctoral thesis . 2010

Einzelmolekülsensoren zur Untersuchung hydrophober Phänomene

Geisler, Michael;
Open Access English
  • Published: 11 Jan 2010
  • Publisher: Technical University of Munich
The nature and magnitude of the hydrophobic interaction is crucial for many technical and biological processes. In the current study a molecular probe was developed which consists of a single polymer that is bound onto the tip of an AFM cantilever in order to study these effects on the molecular scale. In the following, equilibrium forces are measured and factors of influence such as temperature, cosolvents and chemical composition are varied. Thereby, the system under investigation is so small that it can be compared to all-atomistic molecular dynamics simulations. Die Art und Stärke der hydrophoben Wechselwirkung ist entscheidend für zahlreiche technische und ...
free text keywords: Single molecule study, force spectroscopy, force sensor, hydrophobic effect, polymer adhesion, Kraftspektroskopie, Kraftsensor, Hydrophober Effekt, Polymer Haftung, Adhäsion, Biowissenschaften, Biologie, Naturwissenschaften, Physik, ddc:500, ddc:530, ddc:570
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Doctoral thesis . 2010
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301 references, page 1 of 21

Ashbaugh, H.S. and Pratt, L.R. (2006) Colloquium: Scaled particle theory and the length scales of hydrophobicity. Reviews of Modern Physics 78: 159-178. [OpenAIRE]

Yaminsky, V.V. and Vogler, E.A. (2001) Hydrophobic hydration. Current Opinion in Colloid & Interface Science 6: 342-349. [OpenAIRE]

3. Tilden, W.A. ed., Introduction to the study of chemical philosophy: the principles of theoretical and systematic chemistry, 10th ed. (Longmans, Green, and Company, New York, 1901).

Gristina, A.G. (1987) Biomaterial-centered infection: Microbial adhesion versus tissue integration. Science 237: 1588-1595. [OpenAIRE]

Hench, L.L. (2002) Third-generation biomedical materials. Science 295: 1014- 1017. [OpenAIRE]

6. Thakar, R.G. et al. (2008) Contractilitydependent modulation of cell proliferation and adhesion by microscale topographical cues. Small 4: 1416-1424.

Khang, D. et al. (2008) The role of nanometer and sub-micron surface features on vascular and bone cell adhesion on titanium. Biomaterials 29: 970-983. [OpenAIRE]

8. Stickler, D.J. (2008) Bacterial biofilms in patients with indwelling urinary catheters. Nature Clinical Practice Urology 5: 598- 608. [OpenAIRE]

Hall-Stoodley, L., Costerton, J.W., and Stoodley, P. (2004) Bacterial biofilms: From the natural environment to infectious diseases. Nature Reviews Microbiology 2: 95-108.

10. Götz, F. (2002) Staphylococcus anf biofilms. Molecular Microbiology 43: 1367-1378.

11. Costerton, J.W. et al. (1987) Bacterial Biofilms in Nature and Disease. Annual Review of Microbiology 41: 435-464. [OpenAIRE]

12. Matl, F.D. et al. (2008) New anti-infective coatings of medical implants. Antimicrobial Agents and Chemotherapy 52: 1957-1963.

13. Lowe, H.C. and Khachigian, L.M. (2002) Coating stents with antirestenotic drugs: The blunderbuss or the magic bullet? Circulation 105: E29-E29. [OpenAIRE]

14. Bechert, T., Steinrücke, P., and Guggenbichler, J.P. (2000) A new method for screening anti-infective biomaterials. Nature Medicine 6: 1053-1056. [OpenAIRE]

15. Lu, X. et al. (2007) Spectroscopic analysis of titanium surface functional groups under various surface modification and their behaviors in vitro and in vivo. Journal of Biomedical Materials Research 84A: 523- 534.

301 references, page 1 of 21
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