publication . Doctoral thesis . 2011

Zweiphasige Ganzzell-Synthese von R-2-Oktanol mit Wiederverwendung der ionischen Flüssigkeit

Dennewald, Danielle;
Open Access English
  • Published: 13 Dec 2011
  • Publisher: Technical University of Munich
  • Country: Germany
Abstract
Whole-cell biocatalysis in biphasic systems permits the synthesis of inhibiting chiral alcohols if appropriate non-water miscible ionic liquids are used. Taking the asymmetric reduction of 2-octanone to <i>R</i>-2-octanol by a recombinant Escherichia coli as a model reaction, a detailed characterisation of the biocatalytic reaction was performed with [HMPL][NTF] as ionic liquid. This made the asymmetric synthesis of R-2-octanol in a simple batch at a conversion > 99 % and at an enantiomeric excess > 99.5 % possible. The recyclability of the ionic liquid over a large number of cycles including the biotransformation, the separation of the ionic liquid, the product...
Subjects
free text keywords: Chemische Verfahrenstechnik, ddc:660
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Doctoral thesis . 2011
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189 195 Appendices 213 A Abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 213 B Equipment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 220 C Consumables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 222 D Chemicals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223 E Buffers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225 F Culture media . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 226 G Specifications used for the modelling . . . . . . . . . . . . . . . . . . . . . . . 229 H MATLAB code . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231 I Recycling of the ionic liquid . . . . . . . . . . . . . . . . . . . . . . . . . . . . 236

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