publication . Doctoral thesis . 2013

EMMPRIN (CD 147): A potential target in the tumor progression of bladder cancer

Kurzrock, Andreas Robert;
Open Access German
  • Published: 22 Oct 2013
  • Publisher: Technical University of Munich
  • Country: Germany
Abstract
In dieser Studie wurden Expression und Funktion des multifunktionalen Proteins EMMPRIN (CD 147) im Urothelkarzinom (UCa) charakterisiert. EMMPRIN Expression wurde an primärem Tumorgewebe und in UCa Zelllinien nachgewiesen. Es wurden Modelle für die Inhibition der EMMPRIN Expression in vitro etabliert und gezeigt, dass EMMPRIN Einfluss auf Zellzyklus, Apoptose und das Migrationsverhalten hat. EMMPRIN stellt ein potentielles Zielmolekül in der Prognose und Therapie des UCa dar. The present study characterized expression and functional aspects of the multifunctional protein EMMPRIN (CD 147) in urothelial cancer (UCa). EMMPRIN expression was demonstrated in primary ...
Subjects
free text keywords: EMMPRIN, CD 147, Urothelkarzinom, siRNA, EMMPRIN, CD 147, urothelial cancer, siRNA, Medizin und Gesundheit, ddc:610
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