publication . Thesis . 2005

Hypoxic responses in resting hyperthermic humans

Curtis, Andrew;
Open Access English
  • Published: 01 Jan 2005
  • Country: Canada
Abstract
This thesis investigated the interaction between steady state hypoxia and passive hyperthermia on human ventilation and the influence of the PETCO2 on this interaction. On one of two days males twice breathed 12% oxygen for 20 min while either normothermic or hyperthermic with PETCO2 clamped -1 mm Hg above resting (iHVR). On the other day the same tests were performed except P&02 was uncontrolled (pHVR). Hyperthermia increased euoxic ventilation compared to normothermia (plO.OO1). During iHVR ventilation increased more during hyperthermia than normothermia (p=0.002), but not during pHVR (p=0.98). Heart rates at conclusion of pHVR compared to iHVR were greate...
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50 references, page 1 of 4

2.1 Temperature regulation ................................................................................... 3

2.1.1 Physiological responses to cold exposure ...........................................................5

2.1.2 Physiological responses to heat exposure...........................................................7.

2.2 Regulation of ventilation ............................................................................... 11

2.2.1 Ventilatory sensors ..........................................................................................1..2

2.2.2 Central respiratory control ................................................................................. 15

2.2.3 Effector system .................................................................................................. 16

2.3 Overview of control of resting ventilation .................................................... 17

2.3.1 Responses to carbon dioxide .............................................................................17

2.3.2 Responses to pH ..............................................................................................1..8

2.3.3 Responses to oxygen .......................................................................................1..9

2.4 Methodologies for measuring the hypoxic ventilatory response .................. 2 0 2.4.1 Steady-state methods ........................................................................................ 2 1 2.4.2 Progressive HVR methods ................................................................................ 21 2.4.3 Transient methods ............................................................................................2.2 2.4.4 Dynamic end-tidal forcing methods ................................................................2..2

2.5 Factors influencing humans hypoxic ventilatory response ........................... 24

2.5.1 Environmental and age related factors .............................................................2.4

2.5.2 Genetic factors .................................................................................................2..5

50 references, page 1 of 4
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