publication . Thesis . 2010

Non-invasive retinal imaging in mice with fluorescent Scanning Laser Ophthalmoscopy and Fourier Domain Optical Coherence Tomography

Hossein-Javaheri, Nima;
Open Access English
  • Published: 01 Jan 2010
  • Country: Canada
Abstract
Visualization of the internal structures of the retina is critical for clinical diagnosis and monitoring of pathology as well as for medical research investigating the root causes of retinal degeneration. The aim of this thesis is to develop multi-modal non-invasive imaging technology for studying retinal degeneration and gene therapy in mice. We have constructed a FD-OCT prototype and combined it with a Scanning Laser Ophthalmoscope (SLO) to permit real time alignment of the retinal field of view. Fluorescence detection was integrated with the SLO to enable the en face localization of a molecular contrast signal, which is important for retinal angiography and r...
Subjects
Medical Subject Headings: genetic structureseye diseasessense organs
Related Organizations

Sharp, P.F., et al., The scanning laser ophthalmoscope--a review of its role in bioscience and medicine. Phys Med Biol, 2004. 49(7): p. 1085-96.

Emptage, N.J., Fluorescent imaging in living systems. Curr Opin Pharmacol, 2001. 1(5): p. 521-5. [OpenAIRE]

Choma, M.A., et al., Sensitivity advantage of swept-source and Fourier-domain optical coherence tomography. Optics Express, 2003. 11(18): p. 2183-2189.

de Boer, J.F., et al., Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. Optics Letters, 2003. 28(21): p.

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