publication . Preprint . Thesis . 2018

Computational and molecular dissection of an X-box cis-Regulatory module

Warrington, Timothy Burton;
Open Access English
  • Published: 30 Sep 2018
  • Country: Canada
Ciliopathies are a class of human diseases marked by dysfunction of the cellular organelle, cilia. While many of the molecular components that make up cilia have been identified and studied, comparatively little is understood about the transcriptional regulation of genes encoding these components. The conserved transcription factor Regulatory Factor X (RFX)/DAF-19, which acts through binding to the cis-regulatory motif known as X-box, has been shown to regulate ciliary genes in many animals from Caenorhabditis elegans to humans. However, accumulating evidence suggests that RFX is unable to initiate transcription on its own. Therefore, other factors and cis-regul...
free text keywords: Quantitative Biology - Genomics
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