publication . Thesis . 2011

Gene prediction and RFX transcriptional regulation analysis using comparative genomics

Chu, Jeffrey Shih Chieh;
Open Access
  • Published: 23 Feb 2011
  • Country: Canada
Abstract
Regulatory Factor X (RFX) is a family of transcription factors (TF) that is conserved in all metazoans, in some fungi, and in only a few single-cellular organisms. Seven members are found in mammals, nine in fishes, three in fruit flies, and a single member in nematodes and fungi. RFX is involved in many different roles in humans, but a particular function that is conserved in many metazoans is its regulation of ciliogenesis. Probing over 150 genomes for the presence of RFX and ciliary genes led to the understanding of how RFX-cilia regulatory interaction occurred in evolution. Molecular phylogenetic analysis revealed that RFX is only found in metazoans, in some...
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