publication . Doctoral thesis . Other literature type . 2017

Models for Immune Response and Immune Evasion in MSI Cancer and Lynch Syndrome

Özcan, Mine;
Open Access English
  • Published: 01 Jan 2017
  • Country: United States
Abstract
Microsatellite-unstable (MSI) cancers occurring in the context of the hereditary Lynch syndrome or as sporadic cancers elicit pronounced tumor-specific immune responses. The pronounced immune response was shown to be closely associated with frameshift peptides (FSP) that are generated as a result of deficiency in DNA mismatch repair system leading to insertion/deletion mutations in coding microsatellites (cMS). FSP neoantigens are long antigenic amino acid stretches that bear multiple epitopes to be presented. There is no central tolerance against FSPs, and shared FSPs derived from driver mutations are promising candidates for vaccination approaches to treat or ...
Subjects
free text keywords: 500, 500 Natural sciences and mathematics
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publication . Doctoral thesis . Other literature type . 2017

Models for Immune Response and Immune Evasion in MSI Cancer and Lynch Syndrome

Özcan, Mine;