publication . Doctoral thesis . 2000

Transkriptionelle Regulation des Wachstumsfaktors Gastrin beim kleinzelligen- und nichtkleinzelligen Bronchialkarzinom

Zippert, Renate;
Open Access German
  • Published: 01 Jan 2000
  • Publisher: Justus-Liebig-Universität Gießen
  • Country: Germany
Abstract
Die transkriptionelle Regulation der Expression von Gastrin in SCLC- und NSCLC-Zellen war bisher nicht untersucht worden. Die Klonierung der 5´-flankierenden Sequenzen des Gastringens und die Herstellung von Gastrinpromotor-Reportergenkonstrukten ermöglichte eine vergleichende funktionelle Untersuchung der Gastrinpromotor-Aktivität in der SCLC-Zellinie H69, der NSCLC-Zellinie 32M1 und der Mesotheliom-Zellinie MSTO-211H. Die vorliegenden Untersuchungen konnten so eine zelltypspezifische Aktivität des Gastrinpromotors in Lungentumorzellen nachweisen. In der MSTO-211H-Zellinie erwies sich der Gastrinpromotor als praktisch inaktiv. Für die NSCLC-Zellinie EPLC-32M1 u...
Subjects
Medical Subject Headings: respiratory tract diseases
free text keywords: Gastrin, Bronchialkarzinom, transkriptionelle Regulation, Agriculture, ddc:630
Related Organizations
68 references, page 1 of 5

Bepler, G., Koehler, A., Kiefer, P., Havemann, K., Beisenherz, K., Jaques, G., Gropp, C., Haeder, M. (1988). Characterization of the state of differentiation of six newly established human non-small-cell lung cancer cell lines. Differentiation 37: 158-171. [OpenAIRE]

Bigger, C.B., Casanova, E.A., Gardner, P.D. (1996). Transcriptional regulation of neuronal nicotinic acetylcholine receptor genes. J. Biol. Chem. 271: 32842- 32848. [OpenAIRE]

Bigger, C.B., Melnikova, I., Gardner, P.D. (1997). Sp1 and Sp3 regulate expression of the neuronal nicotinic acetylcholine receptor β4 subunit gene. J. Biol. Chem. 272: 25976- 25982.

Birnbaum, M.J., van Wijnen, A.J., Odgren, P.R., Last, T.J., Suske, G., Stein, G.S., Stein, J.L. (1995). Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3. Biochemistry 34: 16503-16508.

Carney, D.N., Gazdar, A.F., Bepler, G., Guccion, J.G., Marangos, P.J., Moody, T.W., Zweig, M.H., Minna, J.D. (1985). Establishment and identification of small cell lung cancer cell lines having classic and variant features. Cancer Res. 45: 2913-2923.

Carney, D.N., Bunn, P.A., Gazdar, A.F., Pagan, J.A., Minna, J.D. (1987). Selective stimulation of small cell lung cancer clonal growth by bombesin and gastrin releasing peptide. Cancer Res. 47: 821-825.

Chiba, I., Takahashi, T., Nau, M.M. et al. (1990). Mutations in the p53 gene are frequent in primary, resected non-small-cell lung cancer. Oncogene 5: 1603-1610. [OpenAIRE]

Chung, D.C., Brand, S.J., Tillotson, L.G. (1995). Mutually exclusive interactions between factors binding to adjacent Sp1 and AT-rich elements regulate gastrin gene transcription in insulinoma cells. J. Biol. Chem. 270: 8829-8836.

D´Amico, D., Carbone, D., Mitsudomi, T., et al. (1992). High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors. Oncogen 7: 339- 346. [OpenAIRE]

Davis, R.L., Cheng, P.F., Lassar, A.B., Weitraub, H. (1990). The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation. Cell 60: 733-746.

Dignam, J.D., Lebovitz, R.M., Roeder, R.G. (1983). Accurate transcription initiation by RNA polymerase II in a soluble extrakt from isolated mammalian nuclei. Nucl. Acids Res. [OpenAIRE]

Dowlati, A., Bury, T., Corhay, J-L., Weber, T., Lamproye, A., Mendes, P., Radermecker, M. (1996). Gastrin levels in serum and bronchoalveolar lavage fluid of patients with lung cancer: comparison with patients with chronic obstructive pulmonary disease. Thorax 51: 1270-1272. [OpenAIRE]

Dynan, W.S. (1989). Modularity in promoters and enhancers. Cell 58: 1-4.

Dynan, W.S., Tjian, R. (1983). The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell 35: 79-87. [OpenAIRE]

Dynan, W.S., Tjian, R. (1985). Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins. Nature 316: 774-778.

68 references, page 1 of 5
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