publication . Doctoral thesis . 2013

Biotechnologische Gewinnung von Cyathan-Diterpenoiden

Shen, Tian;
Open Access German
  • Published: 01 Jan 2013
  • Publisher: Justus-Liebig-Universität Gießen
  • Country: Germany
Abstract
Basidiomyceten produzieren vielfältige biologisch aktive Sekundärmetabolite, unter anderem seltene niedermolekulare Terpenoide, welche ein enormes Potenzial in der pharma¬zeutischen Industrie besitzen. In der vorliegenden Arbeit wurden Unter¬suchungen zu Cyathan-Diterpenoiden aus den Basidiomyceten-Arten Cyathus striatus (FU04405) und Hericium erinaceus (FU70034) durch-geführt. Letzterer ist als Produzent von verschiedenen Erinacinen bekannt. Die Erinacin C-Produktion war bei dem verwendeten Stamm stark substrat¬abhängig. Das ZM1/2-Medium mit 0,5 g L-1 Edamin® K erwies sich dafür als am besten geeignet. Die maximale Konzentration an Erinacin C betrug ca. 257 mg ...
Subjects
free text keywords: Cyathan-Diterpenoide, Erinacine, Hericium erinaceus, MALDI-MS-Imaging, ELISA, Cyathane-Diterpenoids, Chemistry & allied sciences, ddc:540
Related Organizations
63 references, page 1 of 5

Ohta, T., T. Kita, N. Kobayashi, Y. Obara, N. Nakahata, Y. Ohizumi, Y. Takaya, Y. Oshima (1998): Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus. Tetrahedron Lett 39, 1998, S. 6229-6232.

Okamoto, K., T. Sakai, A. Shimada, R. Shirai, H. Sakamoto, S. Yoshida, F. Ojima, Y. Ishiguro, H. Kawagishi (1993): Antimicrobial chlorinated orcinol derivatives from mycelia of Hericium erinaceum. Phytochemistry 34, 1993, S. 1445-1446.

Orihara, N., T. Kuzuyama, S. Takahashi, K. Furihata, H. Seto (1998): Studies on the biosynthesis of terpenoid compounds produced by actinomycetes. 3. Biosynthesis of the isoprenoid side chain of novobiocin via the non-mevalonate pathway in Streptomyces niveus. J Antibiot 51, 1998, S. 676-678. [OpenAIRE]

Park, H. G., H. G. Ko, S. H. Kim, W. M. Park (2004): Molecular identification of asian isolates of medicinal mushroom Hericium erinaceum by phylogenetic analysis of the nuclear ITS rDNA. J Microbiol Biotechn 14, 2004, S. 816-821.

Paterson, R. R. M. (2006): Ganoderma - A therapeutic fungal biofactory. Phytochemistry 67, 2006, S. 1985-2001. [OpenAIRE]

Perez, J., J. Munoz-Dorado, T. de La Rubia, J. Martinez (2002): Biodegradation and biological treatments of cellulose, hemicellulose and lignin: an overview. Int Microbiol 5, 2002, S. 53-63.

Petrova, R. D., J. Mahajna, A. Z. Reznick, S. P. Wasser, C. M. Denchev, E. Nevo (2007): Fungal substances as modulators of NF-κB activation pathway. Mol Biol Rep 34, 2007, S. 145-154.

Peukert, M., A. Matros, G. Lattanzio, S. Kaspar, J. Abadía, H.P. Mock (2012): Spatially resolved analysis of small molecules by matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI). New Phytol 193, 2012, S. 806-815. [OpenAIRE]

Piers, E., M. Gilbert, K. L. Cook (2000): Total synthesis of the cyathane diterpenoid (+/-)-sarcodonin G. Org Lett 2, 2000, S. 1407-1410.

Priya Rani, M., K. Padmakumari (2012): HPTLC and reverse phase HPLC methods for the simultaneous quantification and in vitro screening of antioxidant potential of isolated sesquiterpenoids from the rhizomes of Cyperus rotundus. J Chromatogr B 904, 2012, S. 22-28. [OpenAIRE]

Rabe, U. (1989): Fermentation von Cyathus striatus (Huds. ex Pers.) Willd (Basidiomycetes) und Biosynthese der Striatine. Diss., Universität Kaiserslautern, Deutschland.

Ramírez, D. A., S. V. Muñoz, L. Atehortua, F. C. Michel (2010): Effects of different wavelengths of light on lignin peroxidase production by the white-rot fungi Phanerochaete chrysosporium grown in submerged cultures. Bioresource Technol 101, 2010, S. 9213-9220.

Ricci-Silva, M. E., M. Vitolo, J. Abrahão-Neto (2000): Protein and glucose 6- phosphate dehydrogenase releasing from baker's yeast cells disrupted by a vertical bead mill. Process Biochem 35, 2000, S. 831-835.

Robinson, S., K. Warburton, M. Seymour, M. Clench, J. Thomas-Oates (2007): Localization of water-soluble carbohydrates in wheat stems using imaging matrix-assisted laser desorption ionization mass spectrometry. New Phytol 173, 2007, S. 438-444.

Rohmer, M. (1999): The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants†. Nat Prod Rep 16, 1999, S. 565-574.

63 references, page 1 of 5
Abstract
Basidiomyceten produzieren vielfältige biologisch aktive Sekundärmetabolite, unter anderem seltene niedermolekulare Terpenoide, welche ein enormes Potenzial in der pharma¬zeutischen Industrie besitzen. In der vorliegenden Arbeit wurden Unter¬suchungen zu Cyathan-Diterpenoiden aus den Basidiomyceten-Arten Cyathus striatus (FU04405) und Hericium erinaceus (FU70034) durch-geführt. Letzterer ist als Produzent von verschiedenen Erinacinen bekannt. Die Erinacin C-Produktion war bei dem verwendeten Stamm stark substrat¬abhängig. Das ZM1/2-Medium mit 0,5 g L-1 Edamin® K erwies sich dafür als am besten geeignet. Die maximale Konzentration an Erinacin C betrug ca. 257 mg ...
Subjects
free text keywords: Cyathan-Diterpenoide, Erinacine, Hericium erinaceus, MALDI-MS-Imaging, ELISA, Cyathane-Diterpenoids, Chemistry & allied sciences, ddc:540
Related Organizations
63 references, page 1 of 5

Ohta, T., T. Kita, N. Kobayashi, Y. Obara, N. Nakahata, Y. Ohizumi, Y. Takaya, Y. Oshima (1998): Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus. Tetrahedron Lett 39, 1998, S. 6229-6232.

Okamoto, K., T. Sakai, A. Shimada, R. Shirai, H. Sakamoto, S. Yoshida, F. Ojima, Y. Ishiguro, H. Kawagishi (1993): Antimicrobial chlorinated orcinol derivatives from mycelia of Hericium erinaceum. Phytochemistry 34, 1993, S. 1445-1446.

Orihara, N., T. Kuzuyama, S. Takahashi, K. Furihata, H. Seto (1998): Studies on the biosynthesis of terpenoid compounds produced by actinomycetes. 3. Biosynthesis of the isoprenoid side chain of novobiocin via the non-mevalonate pathway in Streptomyces niveus. J Antibiot 51, 1998, S. 676-678. [OpenAIRE]

Park, H. G., H. G. Ko, S. H. Kim, W. M. Park (2004): Molecular identification of asian isolates of medicinal mushroom Hericium erinaceum by phylogenetic analysis of the nuclear ITS rDNA. J Microbiol Biotechn 14, 2004, S. 816-821.

Paterson, R. R. M. (2006): Ganoderma - A therapeutic fungal biofactory. Phytochemistry 67, 2006, S. 1985-2001. [OpenAIRE]

Perez, J., J. Munoz-Dorado, T. de La Rubia, J. Martinez (2002): Biodegradation and biological treatments of cellulose, hemicellulose and lignin: an overview. Int Microbiol 5, 2002, S. 53-63.

Petrova, R. D., J. Mahajna, A. Z. Reznick, S. P. Wasser, C. M. Denchev, E. Nevo (2007): Fungal substances as modulators of NF-κB activation pathway. Mol Biol Rep 34, 2007, S. 145-154.

Peukert, M., A. Matros, G. Lattanzio, S. Kaspar, J. Abadía, H.P. Mock (2012): Spatially resolved analysis of small molecules by matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI). New Phytol 193, 2012, S. 806-815. [OpenAIRE]

Piers, E., M. Gilbert, K. L. Cook (2000): Total synthesis of the cyathane diterpenoid (+/-)-sarcodonin G. Org Lett 2, 2000, S. 1407-1410.

Priya Rani, M., K. Padmakumari (2012): HPTLC and reverse phase HPLC methods for the simultaneous quantification and in vitro screening of antioxidant potential of isolated sesquiterpenoids from the rhizomes of Cyperus rotundus. J Chromatogr B 904, 2012, S. 22-28. [OpenAIRE]

Rabe, U. (1989): Fermentation von Cyathus striatus (Huds. ex Pers.) Willd (Basidiomycetes) und Biosynthese der Striatine. Diss., Universität Kaiserslautern, Deutschland.

Ramírez, D. A., S. V. Muñoz, L. Atehortua, F. C. Michel (2010): Effects of different wavelengths of light on lignin peroxidase production by the white-rot fungi Phanerochaete chrysosporium grown in submerged cultures. Bioresource Technol 101, 2010, S. 9213-9220.

Ricci-Silva, M. E., M. Vitolo, J. Abrahão-Neto (2000): Protein and glucose 6- phosphate dehydrogenase releasing from baker's yeast cells disrupted by a vertical bead mill. Process Biochem 35, 2000, S. 831-835.

Robinson, S., K. Warburton, M. Seymour, M. Clench, J. Thomas-Oates (2007): Localization of water-soluble carbohydrates in wheat stems using imaging matrix-assisted laser desorption ionization mass spectrometry. New Phytol 173, 2007, S. 438-444.

Rohmer, M. (1999): The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants†. Nat Prod Rep 16, 1999, S. 565-574.

63 references, page 1 of 5
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