publication . Doctoral thesis . 2003

Vergleichende Analyse der Expression des Glukokortikoid-Rezeptors und der NF-kappaB Untereinheit p50 in Lymphozyten von Patienten mit rheumatoider Arthritis und Gesunden

Klüter, Andreas;
Open Access German
  • Published: 01 Jan 2003
  • Publisher: Justus-Liebig-Universität Gießen
  • Country: Germany
Abstract
<i>Zielstellung</i>: Es wurden die Expression des antiinflammatorisch wirkenden Transkriptionsfaktors Glukokortikoid-Rezeptor (GR) und der Untereinheit p50 des proinflammatorischen Transkriptionsfaktor NF-kappaB in peripheren mononuklearen Blutzellen (PBMC) von Patienten mit rheumatoider Arthritis (RA) untersucht. <br><br><i>Methode</i>: Es wurden unbehandelte und mit Glukokortikoiden vorbehandelte RA-Patienten sowie gesunde Probanden verglichen. Die Expressionsanalyse von GR und der NF-kappaB Untereinheit p50 in peripheren PMBC's, welche zuvor durch Gradientenzentrifugation isoliert wurden, wurde mittels semiquantitativem Immunoblotting durchgeführt. <br><br><i...
Subjects
free text keywords: Glukokortikoid Rezeptor, Rheumatoide Arthritis, NF-kappaB, Lymphozyten, Medical sciences Medicine, ddc:610
Related Organizations
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