publication . Doctoral thesis . 2015

Identification of pulmonary PDGFRalpha-positive fibroblast specific miRNA and mRNA expression profiles during postnatal lung development

Dontireddy, Daria Agnieszka;
Open Access English
  • Published: 01 Jan 2015
  • Publisher: Justus-Liebig-Universität Gießen
  • Country: Germany
Abstract
BACKGROUND AND AIM The process of alveolarization is tightly regulated and requires the contribution of different subpopulations of fibroblasts such as myofibroblasts, lipofibroblasts and platelet-derived growth factor receptor alpha (PDGFRalpha)-positive fibroblasts. Each of this fibroblasts subset fulfills certain functions during lung development in a time-dependent manner. In particular PDGFRalpha-positive cells are crucial for alveolar septation and myofibroblasts differentiation. PDGF-A deletion in vivo leads to a disruption of septum formation in mice. Therefore, we aimed to characterize PDGFRalpha-positive fibroblasts specific miRNA and mRNA expression p...
Subjects
free text keywords: Medical sciences Medicine, ddc:610
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